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OpenTrials
Completed

NCT Number: NCT02229487

The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Hypothesis

1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Completed

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Key information

Conditions

PreDiabetes Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases Prediabetic State

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Ramathibodi Hospital

Bangkok, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital
  • Age 18 or older
  • Can understand Thai (speaking, listening and reading)
  • Agree to participate by written informed consent

Exclusion criteria

  • Those who depend on others for feeding (such as stroke patients)
  • Shift workers
  • History of congestive heart failure or low ejection fraction
  • Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT > 3 times the upper limit of normal)
  • Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin
  • Patients with permanent pacemaker
  • History of previous stroke

Treatment and study plan

Oral glucose tolerance

Other

Primary outcomes

  1. GLP-1 Levels in Response to Oral Glucose Tolerance Test

    Time frame: 2 weeks

    Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels

Interested in participating?

Completed

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Sponsors and collaborators

Lead sponsor

Ramathibodi Hospital

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Acronym: Sleep GLP-1

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Sep 1, 2014
Registry last updated
Oct 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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