Moringa Leaf Powder for Prediabetes

This was a prospective, randomized, double-blind, placebo-controlled, parallel-group clinical trial conducted in a primary care setting in Bekasi, Indonesia. The study evaluated the effect of Moringa oleifera leaf powder on fasting blood glucose over 90 days in adults with prediabetes.

Eligible participants were adults aged 25 to 55 years with fasting blood glucose levels of 100-125 mg/dL who had not used oral antidiabetic medication or insulin during the preceding 3 months. After providing informed consent, 114 participants were randomly assigned in a 1:1 ratio to the Moringa oleifera leaf powder group or the placebo group.

Participants in the intervention group received 2,400 mg of Moringa oleifera leaf powder daily as six 400-mg capsules, taken as two capsules three times daily after meals for 90 days. Participants in the control group received matching microcrystalline cellulose placebo capsules according to the same schedule.

Fasting blood glucose was measured at baseline and every 3 days through day 90. The primary objective was to compare the longitudinal pattern of fasting blood glucose between the two groups. Treatment adherence and unwanted health effects were also monitored throughout the study.

Inclusion criteria

• Fasting blood glucose levels of 100-125 mg/dL
• Who had not received oral antidiabetic medications or insulin within the previous three months
• Had provided written informed consent

Exclusion criteria

• Individuals with hypertension or other significant comorbid medical conditions