Vascular Function on the First Day After Cardiac Surgery

This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique. Increased flow is achieved trough obstructing blood flow with a cuff around the forearm for five minutes. FMD is measured before surgery and on the first morning after the operation.

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Key information

Conditions

Coronary Artery Disease Aneurysm Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

30 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

St. Olavs Hospital

Trondheim, Sør Trøndelag, 7006, Norway

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

admitted for coronary artery bypass surgery

Exclusion criteria

Ongoing treatment with nitrates or RAAS inhibiting drugs
unstable coronary syndrome
unstable circulation/shock
renal failure
hepatic failure
autoimmune or inflammatory disease
untreated hypertension.

Treatment and study plan

Primary outcomes

flow mediated dilation of the brachial artery

Time frame: one day

Transitory change in FMD as a consequence of cardiac surgery with use of extra corporal circulation.

Secondary outcomes

Reactive hyperemia

Time frame: one day

Transitory change in reactive hyperemia after five minutes of occlusion of forearm blood flow as a consequence of cardiac surgery with the use of extra corporal circulation.

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

St. Olavs Hospital

Registry information

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Dec 4, 2013
Registry last updated: Sep 19, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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