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Completed

NCT Number: NCT03655041

24-Wk β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males

Although β-alanine (BA) has been shown to be an effective ergogenic aid, little information exists on the safety of chronic supplementation despite potential concerns. The aim of this study was to investigate the effects of chronic BA supplementation on muscle taurine content, blood clinical markers and sensory side-effects during 24 weeks of BA supplementation.

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Key information

Conditions

Sports Nutritional Physiological Phenomena

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy males

Exclusion criteria

  • Smokers
  • Chronic disease
  • Prior or current use of steroids
  • Use of creatine in the last 6 months
  • Use of beta-alanine in the last 6 months

Treatment and study plan

Beta-alanine

Dietary Supplement

Beta-alanine in sustained-release tablets to increase muscle carnosine content

Placebo

Dietary Supplement

Maltodextrin is used as a placebo as it does not lead to any increases in muscle carnosine

Primary outcomes

  1. Muscle taurine content in mmol/kg

    Time frame: Up to 24 weeks

    Change in the content of taurine in muscle will be determined using High-Pressure Liquid Chromatography of muscle biopsies

Secondary outcomes

  1. Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase in U/L

    Time frame: Up to 24 weeks

    Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase will be analysed from venous blood samples

  2. Albumin; globulin; creatinine in mg/dL

    Time frame: Up to 24 weeks

    Albumin; globulin; creatinine will be analysed from venous blood samples

Sponsors and collaborators

Lead sponsor

University of Sao Paulo

Other

Registry information

Official study title

24-Weeks of β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males

Important dates

Study start
2013
Primary completion
2015
Study completion
2017
First posted
Aug 31, 2018
Registry last updated
Aug 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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