11C-PIB PET Study in MESA at Columbia University

This is a single center PET study of 11C-PIB. Eligible participants are current participants in the MESA study in New York City, without contraindications to MRI or PET procedures. Those eligible will have one brain PET scan with 11C-PIB within 12 months of a brain MRI. Vital signs will be checked prior to injection of 11C-PIB, 10 minutes after the injection, and again at the completion of the PET scan. The primary outcome measure for amyloid will be whole brain 11C-PIB SUVR. The relation between exposure groups and amyloid in the brain will be analyzed using linear regression.

Inclusion criteria

• Current participants in MESA study at Columbia University
• 60 years or older
• Fluent in English and/or Spanish.
• Able to participate in all scheduled evaluations and to complete all required tests and procedures.

Exclusion criteria

• Active treatment for cancer
• Any serious medical condition which would prevent long-term participation
• Pregnancy
• Weight >300 pounds
• Participants previously diagnosed or adjudicated to have dementia
• Participants unwilling to undergo cognitive testing
• Plans to leave the community within five years
• Language barrier (speaks other than English, Spanish, Chinese)
• Inability to give informed consent or to obtain consent from a Legally Authorized Representative (LAR)