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Clinical trial condition

Proteostasis Deficiencies

Explore clinical trials studying Proteostasis Deficiencies. Study availability and eligibility vary by location and protocol.

1,350 public trials 353 recruiting studies
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Proteostasis Deficiencies trial results

Active, Not Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)

NCT05262023

Conditions
Brain Diseases, Central Nervous System Diseases, Dementia, +10 more
Locations
  • University of California San Francisco San Francisco, California, United States
  • John Hopkins University Baltimore, Maryland, United States
  • Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States
  • University of Antwerp Antwerp, Belgium
View all 26 locations
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Active, Not Recruiting

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

NCT04153149

Conditions
Amyloidosis, Amyloidosis, Familial, Amyloidosis, Hereditary, Transthyretin-Related, +10 more
Locations
  • Clinical Trial Site La Mesa, California, United States
  • Clinical Trial Site Los Angeles, California, United States
  • Clinical Trial Site Stanford, California, United States
  • Clinical Trial Site Washington D.C., District of Columbia, United States
View all 119 locations
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Active, Not Recruiting

ALS Phase II Study of NX210c

NCT06365216

Conditions
Amyotrophic Lateral Sclerosis, Central Nervous System Diseases, Metabolic Diseases, +8 more
Locations
  • Centre Hospitalier Regional Et Universitaire De Brest Brest, France
  • Centre Hospitalier Universitaire De Caen Normandie Caen, France
  • Hôpital La Timone - APHM Marseille, France
  • CHRU De Nancy Nancy, France
View all 16 locations
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Active, Not Recruiting

Amyloidosis TTR Flow Reserve Evaluation

NCT05103943

Conditions
Amyloid Cardiomyopathy, Amyloid Neuropathies, Amyloid Neuropathies, Familial, +13 more
Locations
  • CHU d'ANGERS Angers, France
  • CHU Caen Caen, France
  • CHU Orleans Orléans, France
  • CHRU de TOURS Tours, France
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Active, Not Recruiting

Study of Re-Treatment With ALXN2220 in Patients With ATTR-CM

NCT07213583

Conditions
Amyloid Transthyretin Cardiomyopathy, Amyloidosis, Metabolic Diseases, +2 more
Locations
  • Hôpital Henri Mondor Créteil, France
  • CHU de Rennes - Hôpital Pontchaillou Rennes, France
  • CHU Toulouse - Hôpital Rangueil Toulouse, France
  • Universitätsklinikum Heidelberg Heidelberg, Germany
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Active, Not Recruiting

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

NCT05299658

Conditions
Amyotrophic Lateral Sclerosis, Central Nervous System Diseases, Metabolic Diseases, +8 more
Locations
  • Concord Hospital Concord, New South Wales, Australia
  • Neuroscience Research Australia Randwick, New South Wales, Australia
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Active, Not Recruiting

Ixazomib Maintenance Study in Patients With AL Amyloidosis

NCT03618537

Conditions
AL Amyloidosis, Amyloidosis, Immune System Diseases, +10 more
Locations
  • Tufts Medical Center Boston, Massachusetts, United States
  • Memorial Sloan Kettering Basking Ridge Basking Ridge, New Jersey, United States
  • Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States
  • Memorial Sloan Kettering Bergen Montvale, New Jersey, United States
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