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Clinical trial condition

Neurodegenerative Diseases

Explore clinical trials studying Neurodegenerative Diseases. Study availability and eligibility vary by location and protocol.

8,965 public trials 1,748 recruiting studies
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Neurodegenerative Diseases trial results

Active, Not Recruiting

A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants With Spinal Muscular Atrophy (SMA) Who Were Previously Treated With Risdiplam (ASCEND)

NCT05067790

Conditions
Central Nervous System Diseases, Motor Neuron Disease, Muscular Atrophy, Spinal, +5 more
Locations
  • Barrow Neurological Institute Phoenix, Arizona, United States
  • Stanford Neuroscience Health Center Palo Alto, California, United States
  • Rare Disease Research, LLC Atlanta, Georgia, United States
  • Boston Children's Hospital Boston, Massachusetts, United States
View all 22 locations
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Active, Not Recruiting

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

NCT05686551

Conditions
Basal Ganglia Diseases, Brain Diseases, Central Nervous System Diseases, +13 more
Locations
  • Uab Medicine Birmingham, Alabama, United States
  • Barrow Neurological Institute Phoenix, Arizona, United States
  • University of California Davis Medical System Sacramento, California, United States
  • CenExel Rocky Mountain Clinical Research, LLC Englewood, Colorado, United States
View all 70 locations
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Active, Not Recruiting

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

NCT05101148

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Genetic Diseases, Inborn, Heredodegenerative Disorders, Nervous System, +14 more
Locations
  • Research Site Rochester, Minnesota, United States
  • Research Site Akron, Ohio, United States
  • Research Site Bydgoszcz, Poland
  • Research Site Gdansk, Poland
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Active, Not Recruiting

A Double-blind Dual Study Assessing Safety and Efficacy of Buntanetap in Participants With Early AD

NCT06709014

Conditions
Alzheimer Disease, Brain Diseases, Central Nervous System Diseases, +9 more
Locations
  • MD First Research Chandler, Arizona, United States
  • Xenoscience Phoenix, Arizona, United States
  • Clinical Endpoints Scottsdale, Arizona, United States
  • Advanced Research Center Anaheim, California, United States
View all 78 locations
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Active, Not Recruiting

A Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodromal Stage of Alzheimer's Disease (AD)

NCT06402838

Conditions
Alzheimer Disease, Alzheimer's Disease, Brain Diseases, +7 more
Locations
  • Centro de Investigación Clínica UC-CICUC Santiago, Chile
  • Hospital Clinico Univ de Chile Santiago, Chile
  • Aarhus Universitetshospital Skejby Aarhus N, Denmark
  • Rigshospitalet, Hukommelsesklinikken Koebenhavn Oe, Denmark
View all 46 locations
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Active, Not Recruiting

RESET-MG: A Study to Evaluate the Safety and Efficacy of CABA-201 in Participants With Generalized Myasthenia Gravis

NCT06359041

Conditions
Autoimmune Diseases, Autoimmune Diseases of the Nervous System, Generalized Myasthenia Gravis (gMG), +11 more
Locations
  • University of California Irvine Orange, California, United States
  • UC Davis, Department of Neurology Sacramento, California, United States
  • University of California, San Francisco San Francisco, California, United States
  • University of Colorado Aurora, Colorado, United States
View all 17 locations
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Active, Not Recruiting

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

NCT04747431

Conditions
Brain Diseases, C9orf72, Central Nervous System Diseases, +16 more
Locations
  • Michigan Alzheimer's Disease Center Ann Arbor, Michigan, United States
  • University of Pennsylvania Philadelphia, Pennsylvania, United States
  • Vanderbilt University Medical Center Nashville, Tennessee, United States
  • University of Texas at Houston Houston, Texas, United States
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