Skip to main content
OpenTrials

Clinical trial condition

Depressive Disorder, Major

Explore clinical trials studying Depressive Disorder, Major. Study availability and eligibility vary by location and protocol.

2,302 public trials 328 recruiting studies
Refine in advanced search Browse all conditions

Depressive Disorder, Major trial results

Completed

A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

NCT03321526

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • NoesisPharma Research Phoenix, Arizona, United States
  • Clinical Research Consortium Arizona Tempe, Arizona, United States
  • Woodland Research Northwest Rogers, Arkansas, United States
  • Collaborative NeuroScience Network Garden Grove, California, United States
View all 50 locations
View Trial Details
Completed

A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide

NCT02133001

Conditions
Depressive Disorder, Depressive Disorder, Major, Major Depressive Disorder, +2 more
Locations
  • Birmingham, Alabama, United States
  • San Diego, California, United States
  • Hartford, Connecticut, United States
  • New Haven, Connecticut, United States
View all 14 locations
View Trial Details
Completed

54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide

NCT03097133

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • University of California San Diego/Psychiatry San Diego, California, United States
  • Sharp Mesa Vista Hospital San Diego, California, United States
  • University of Conneticut School of Medicine Farmington, Connecticut, United States
  • University of Miami Health System Miami, Florida, United States
View all 61 locations
View Trial Details
Completed

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder

NCT04338321

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • Fundacion para el Estudio y Tratamiento de las Enfermedades Mentales Buenos Aires, Argentina
  • FunDaMos Buenos Aires, Argentina
  • CEN Consultorios Especializados en Neurociencias Córdoba, Argentina
  • Fundacion Lennox Córdoba, Argentina
View all 171 locations
View Trial Details
Completed

A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

NCT03227224

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • California Pharmaceutical Research Institute, Inc. Anaheim, California, United States
  • Catalina Research Institute Chino, California, United States
  • Synergy Clinical Research Center Of Escondido Lemon Grove, California, United States
  • Asclepes Research Panorama City, California, United States
View all 101 locations
View Trial Details
Completed

A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression

NCT03559192

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • Noble Clinical Research Tucson, Arizona, United States
  • Preferred Research Partners Little Rock, Arkansas, United States
  • Behavioral Research Specialists LLC Glendale, California, United States
  • NRC Research Institute Orange, California, United States
View all 53 locations
View Trial Details

Related conditions