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Clinical trial condition

Depressive Disorder

Explore clinical trials studying Depressive Disorder. Study availability and eligibility vary by location and protocol.

2,792 public trials 428 recruiting studies
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Depressive Disorder trial results

Completed

A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

NCT03321526

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • NoesisPharma Research Phoenix, Arizona, United States
  • Clinical Research Consortium Arizona Tempe, Arizona, United States
  • Woodland Research Northwest Rogers, Arkansas, United States
  • Collaborative NeuroScience Network Garden Grove, California, United States
View all 50 locations
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Completed

A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide

NCT02133001

Conditions
Depressive Disorder, Depressive Disorder, Major, Major Depressive Disorder, +2 more
Locations
  • Birmingham, Alabama, United States
  • San Diego, California, United States
  • Hartford, Connecticut, United States
  • New Haven, Connecticut, United States
View all 14 locations
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Completed

54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide

NCT03097133

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • University of California San Diego/Psychiatry San Diego, California, United States
  • Sharp Mesa Vista Hospital San Diego, California, United States
  • University of Conneticut School of Medicine Farmington, Connecticut, United States
  • University of Miami Health System Miami, Florida, United States
View all 61 locations
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Completed

A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

NCT02493868

Conditions
Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mental Disorders, +1 more
Locations
  • Birmingham, Alabama, United States
  • Little Rock, Arkansas, United States
  • Anaheim, California, United States
  • Garden Grove, California, United States
View all 155 locations
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Completed

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder

NCT04338321

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • Fundacion para el Estudio y Tratamiento de las Enfermedades Mentales Buenos Aires, Argentina
  • FunDaMos Buenos Aires, Argentina
  • CEN Consultorios Especializados en Neurociencias Córdoba, Argentina
  • Fundacion Lennox Córdoba, Argentina
View all 171 locations
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Completed

A Study to Evaluate the Efficacy and Safety of JNJ-42847922 as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy

NCT03227224

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • California Pharmaceutical Research Institute, Inc. Anaheim, California, United States
  • Catalina Research Institute Chino, California, United States
  • Synergy Clinical Research Center Of Escondido Lemon Grove, California, United States
  • Asclepes Research Panorama City, California, United States
View all 101 locations
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Completed

A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

NCT03434041

Conditions
Depressive Disorder, Depressive Disorder, Treatment-Resistant, Mental Disorders, +1 more
Locations
  • Atlanta Center for Medical Research Atlanta, Georgia, United States
  • Biomedical Research Foundation of Northwest Louisiana Shreveport, Louisiana, United States
  • CBH Health Gaithersburg, Maryland, United States
  • Adams Clinical Watertown, Massachusetts, United States
View all 30 locations
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Completed

A Study to Explore the Efficacy of JNJ-67953964 in the Treatment of Depression

NCT03559192

Conditions
Depressive Disorder, Depressive Disorder, Major, Mental Disorders, +1 more
Locations
  • Noble Clinical Research Tucson, Arizona, United States
  • Preferred Research Partners Little Rock, Arkansas, United States
  • Behavioral Research Specialists LLC Glendale, California, United States
  • NRC Research Institute Orange, California, United States
View all 53 locations
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