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Recruiting

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

NCT04166409

Conditions
Low Grade Astrocytoma, Low Grade Glioma, Metastatic Low Grade Astrocytoma, +3 more
Locations
  • Children's Hospital of Alabama Birmingham, Alabama, United States
  • Banner Children's at Desert Mesa, Arizona, United States
  • Phoenix Childrens Hospital Phoenix, Arizona, United States
  • Arkansas Children's Hospital Little Rock, Arkansas, United States
View all 132 locations
View Trial Details
Recruiting

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

NCT05538130

Conditions
Advanced or Metastatic Solid Tumors, Brain Diseases, Brain Neoplasms, +41 more
Locations
  • The Kirklin Clinic of UAB Hospital Birmingham, Alabama, United States
  • The University of Alabama at Birmingham Birmingham, Alabama, United States
  • University of Alabama at Birmingham - Phase I Clinical Trials Unit Birmingham, Alabama, United States
  • Highlands Oncology Group, PA Fayetteville, Arkansas, United States
View all 83 locations
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Completed

Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)

NCT03213665

Conditions
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Non-Hodgkin Lymphoma, +91 more
Locations
  • Children's Hospital of Alabama Birmingham, Alabama, United States
  • Providence Alaska Medical Center Anchorage, Alaska, United States
  • Banner Children's at Desert Mesa, Arizona, United States
  • Phoenix Childrens Hospital Phoenix, Arizona, United States
View all 117 locations
View Trial Details
Completed

Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

NCT03233204

Conditions
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, +85 more
Locations
  • Children's Hospital of Alabama Birmingham, Alabama, United States
  • Providence Alaska Medical Center Anchorage, Alaska, United States
  • Banner Children's at Desert Mesa, Arizona, United States
  • Banner University Medical Center - Tucson Tucson, Arizona, United States
View all 113 locations
View Trial Details
Completed

ROCOCO - Low Grade Glioma - Planning Study

NCT02607397

Conditions
Low Grade Glioma
Locations
  • University of Heidelberg Heidelberg, Germany
  • University Hospital Giessen and Marburg Marburg, Germany
  • Radiotherapy Group Deventer, Netherlands
  • University Medical Center Nijmegen Nijmegen, Netherlands
View Trial Details
Active, Not Recruiting

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

NCT03871257

Conditions
Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Genetic Diseases, Inborn, Heredodegenerative Disorders, Nervous System, +16 more
Locations
  • Children's Hospital of Alabama Birmingham, Alabama, United States
  • Banner Children's at Desert Mesa, Arizona, United States
  • Phoenix Childrens Hospital Phoenix, Arizona, United States
  • Arkansas Children's Hospital Little Rock, Arkansas, United States
View all 132 locations
View Trial Details
Active, Not Recruiting

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

NCT01089101

Conditions
Astrocytoma, Congenital, Hereditary, and Neonatal Diseases and Abnormalities, Genetic Diseases, Inborn, +25 more
Locations
  • Children's Hospital Los Angeles Los Angeles, California, United States
  • Lucile Packard Children's Hospital Stanford University Palo Alto, California, United States
  • UCSF Medical Center-Mount Zion San Francisco, California, United States
  • UCSF Medical Center-Parnassus San Francisco, California, United States
View all 17 locations
View Trial Details
Active, Not Recruiting

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

NCT03749187

Conditions
Astrocytoma, Glioblastoma, Glioma, +16 more
Locations
  • Children's Hospital Los Angeles Los Angeles, California, United States
  • University of California, San Francisco San Francisco, California, United States
  • Yale University New Haven, Connecticut, United States
  • Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States
View Trial Details