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Recruiting

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

NCT06317662

Conditions
Acute Leukemia of Ambiguous Lineage, B Acute Lymphoblastic Leukemia, Burkitt Lymphoma, +20 more
Locations
  • Children's Hospital of Alabama Birmingham, Alabama, United States
  • Providence Alaska Medical Center Anchorage, Alaska, United States
  • Banner Children's at Desert Mesa, Arizona, United States
  • Arkansas Children's Hospital Little Rock, Arkansas, United States
View all 113 locations
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Recruiting

A Multicenter Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-Cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymph...

NCT05621291

Conditions
Acute Lymphoblastic Leukemia, B-ALL, Hematologic Diseases, +10 more
Locations
  • Children's Hospital of Los Angeles Los Angeles, California, United States
  • Children's National Medical Center Washington D.C., District of Columbia, United States
  • Children's Healthcare of Atlanta Atlanta, Georgia, United States
  • National Institutes of Health Clinical Center Bethesda, Maryland, United States
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Recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

NCT04269902

Conditions
Chronic Disease, Chronic Lymphocytic Leukemia, Disease Attributes, +15 more
Locations
  • University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States
  • Anchorage Associates in Radiation Medicine Anchorage, Alaska, United States
  • Anchorage Radiation Therapy Center Anchorage, Alaska, United States
  • Alaska Breast Care and Surgery LLC Anchorage, Alaska, United States
View all 631 locations
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Recruiting

Personalized NK Cell Therapy in CBT

NCT02727803

Conditions
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Lymphoblastic Leukemia, +55 more
Locations
  • M D Anderson Cancer Center Houston, Texas, United States
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Recruiting

First-in-human Study of a New Treatment (4A10) for Patients With Relapsed or Hard-to-treat Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma, Focused on Safety and How the Drug Behaves in the Body and Early Signs of Effect.

NCT07586618

Conditions
Acute Lymphoblastic Leukemia ALL, Disease Attributes, Hematologic Diseases, +14 more
Locations
  • Children's Hospital Colorado Aurora, Colorado, United States
  • Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States
  • Cook Children's Medical Center Fort Worth, Texas, United States
  • Texas Children's Hospital Houston, Texas, United States
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Recruiting

A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

NCT07020533

Conditions
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, +38 more
Locations
  • City of Hope Medical Center Duarte, California, United States
  • Northside Hospital Atlanta, Georgia, United States
  • Brigham and Women's Hospital Boston, Massachusetts, United States
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Recruiting

A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).

NCT05947851

Conditions
CLL, Chronic Disease, Disease Attributes, +18 more
Locations
  • Highlands Oncology Group ( Site 5405) Springdale, Arkansas, United States
  • MemorialCare Health System - Long Beach Medical Center ( Site 5421) Long Beach, California, United States
  • Memorial Hospital West ( Site 5410) Pembroke Pines, Florida, United States
  • Oregon Health and Science University ( Site 5425) Portland, Oregon, United States
View all 55 locations
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Recruiting

Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)

NCT04728893

Conditions
Blood Protein Disorders, Cardiovascular Diseases, Chronic Lymphocytic Leukaemia, +24 more
Locations
  • Highlands Oncology Group ( Site 2728) Springdale, Arkansas, United States
  • University of California San Diego Moores Cancer Center ( Site 2717) La Jolla, California, United States
  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA-Hematology and Medical Oncology ( Site 2724) Torrance, California, United States
  • Colorado Blood Cancer Institute ( Site 2726) Denver, Colorado, United States
View all 121 locations
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Recruiting

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187

Conditions
Chronic Disease, Chronic Lymphocytic Leukemia, Disease Attributes, +15 more
Locations
  • University of Alabama At Birmingham Hospital Birmingham, Alabama, United States
  • Mayo Clinic Phoenix Phoenix, Arizona, United States
  • Kaiser Permanente Southern California Irvine, California, United States
  • University of California San Diego (Ucsd) Moores Cancer Center La Jolla, California, United States
View all 197 locations
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