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Recruiting

Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection

NCT07435649

Conditions
Central Nervous System Diseases, Central Nervous System Infection, Central Nervous System Infections, +2 more
Locations
  • University of California at San Francisco at Zuckerberg San Francisco General San Francisco, California, United States
  • Emory University Hospital Atlanta, Georgia, United States
  • Lahey Hospital & Medical Center Burlington, Massachusetts, United States
  • Vanderbilt University Medical Center Nashville, Tennessee, United States
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Recruiting

Evaluation of Patients With HAM/TSP

NCT00001778

Conditions
Central Nervous System Diseases, Central Nervous System Infections, Deltaretrovirus Infections, +14 more
Locations
  • National Institutes of Health Clinical Center Bethesda, Maryland, United States
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Recruiting

Fungal Infection Susceptibility

NCT00001352

Conditions
Bacterial Infections and Mycoses, Central Nervous System Diseases, Central Nervous System Fungal Infections, +13 more
Locations
  • National Institutes of Health Clinical Center Bethesda, Maryland, United States
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Recruiting

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

NCT07100990

Conditions
Autoimmune Diseases, Autoimmune Diseases of the Nervous System, Central Nervous System Diseases, +20 more
Locations
  • Mayo Clinic Arizona Scottsdale, Arizona, United States
  • Loma Linda University Loma Linda, California, United States
  • University of California, Davis Sacramento, California, United States
  • University of Colorado - Anschutz Medical Aurora, Colorado, United States
View all 33 locations
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Recruiting

DON in Pediatric Cerebral Malaria

NCT05478720

Conditions
Central Nervous System Diseases, Central Nervous System Infections, Central Nervous System Parasitic Infections, +10 more
Locations
  • Ndirande Research Clinic Blantyre, Malawi
  • Queen Elizabeth Central Hospital Blantyre, Malawi
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Recruiting

Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis

NCT04145258

Conditions
Actinomycetales Infections, Bacterial Infections, Bacterial Infections and Mycoses, +15 more
Locations
  • Cocody University Hospital Abidjan, Côte d’Ivoire
  • Treichville University Hospital Abidjan, Côte d’Ivoire
  • Yopougon University Hospital Abidjan, Côte d’Ivoire
  • University Hospital Joseph Raseta Befelatanana Antananarivo, Madagascar
View all 13 locations
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Recruiting

Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC

NCT05491525

Conditions
Autoimmune Diseases, Autoimmune Diseases of the Nervous System, Central Nervous System Diseases, +30 more
Locations
  • Arkansas Childrens Hospital Little Rock, Arkansas, United States
  • Children's Hospital of Orange County Orange, California, United States
  • Children's Hospital Colorado Aurora, Colorado, United States
  • Nemours Childrens Health, Jacksonville Jacksonville, Florida, United States
View all 38 locations
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Recruiting

PrP-targeting siRNA Safety & Mechanism Study

NCT07444580

Conditions
Brain Diseases, Central Nervous System Diseases, Central Nervous System Infections, +18 more
Locations
  • Massachusetts General Hospital Boston, Massachusetts, United States
  • Mayo Clinic Rochester, Minnesota, United States
  • Columbia University Medical Center New York, United States
  • University Hospitals Cleveland Medical Center Cleveland, Ohio, United States
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Recruiting

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis

NCT05383742

Conditions
Actinomycetales Infections, Bacterial Infections, Bacterial Infections and Mycoses, +15 more
Locations
  • Hospital Nossa Senhora da Conceicao CRS (Site ID: 12201) Porto Alegre, Brazil
  • Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS (Site ID: 12101) Rio de Janeiro, Brazil
  • Byramjee Jeejeebhoy Government Medical College (BJMC) CRS (Site ID: 31441) Pune, India
  • Moi University Clinical Research Center (MUCRC) CRS (Site ID: 12601) Eldoret, Kenya
View all 18 locations
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Recruiting

Adjunctive Doxycycline for Central Nervous System Tuberculosis

NCT06446245

Conditions
Actinomycetales Infections, Bacterial Infections, Bacterial Infections and Mycoses, +20 more
Locations
  • Adam Malik Hospital Medan, Indonesia
  • Universitas Sumatera Utara Medan, Indonesia
  • Murni Teguh Memorial Hospital Medan, Indonesia
  • Sarawak General Hospital Kuching, Sarawak, Malaysia
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