Zoonotic Influenza Infections of Swine Origin at Ohio Agricultural Fairs

Background:

- The flu is a very infectious and contagious virus that affects both people and pigs. Studies show that pigs can be sources of the flu virus in humans. Researchers want to know more about how the flu is transmitted from animals to people. If they know more about it, they can find better ways to prevent the flu and treat people who get sick from it.

Objective:

- To discover if flu viruses can be found in people exposed to pigs at Ohio agricultural fairs.

Eligibility:

- Volunteers 8 years of age and older who exhibit pigs at Ohio agricultural fairs.

Design:

* Before or on the first day of the fair, participants will fill out a short demographic and medical history form. They will also complete a two-page symptom questionnaire. This is a form that asks them about any flu symptoms they might have. * Participants will have a nasal swab performed. The inside of the participant s nose will be rubbed with a swab to collect nasal fluid. * Researchers will see participants 2 days later and 4 days later. During these visits, participants will again fill out a symptom questionnaire and have a nasal swab.

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Key information

Conditions

Influenza Infections Influenza, Human Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

8 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ohio State University, College of Veterinary Medicine

Columbus, Ohio, 43210-1240, United States

About this study

The bidirectional transmission of influenza A viruses between animals and humans are clearly an important part of the complex dynamics of influenza evolution, however a thorough understanding of this process remains a mystery. The role of swine in overall human influenza evolution is unclear, but a long history of the study of swine origin influenza has revealed that influenza evolves in swine populations both in North America and Europe.

In 2009, a pandemic occurred with the emergence of the H1N1 pandemic (pdm) virus which was found to have originated from both a North American and European swine lineage, again reinforcing how viruses evolving in swine can lead to important human pathogens. Interestingly this virus was transmitted back into swine and birds in North America. In 2011, an H3N2 swine origin influenza virus known as the H3N2v and containing the H1N1pdm matrix genomic segment was reported causing human infections in multiple parts of the US. In 2012, these cases increased, especially during the summer months. Since 2011, 321 confirmed cases have been reported from 13 states including 107 cases in Ohio. Almost all of these cases have been linked to swine exposure on farms or at agricultural fairs.

Study of these zoonotic transmission events at agricultural fairs are necessary in order to better understand how and why these events occur, how human pathogens emerge, and how to potentially prevent events from occurring. These events could lead to new pandemics and epidemics so their prevention is crucial. The goal of this study is to examine rates of bidirectional zoonotic transmission at Ohio agricultural fairs. Through collection of viruses and host samples, we hope to begin to answer questions regarding how viruses cross species barriers, adapt to new hosts, and how these events could impact overall influenza virus evolution.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:
Volunteers greater than or equal to 8 years of age
Parental consent if a participant is less than 18 years of age
Willing to have samples stored for future research
Willingness to complete all study procedures
Daily or nearly daily contact with swine during selected agricultural fairs

Exclusion criteria

Any medical condition or circumstance that may make it unsafe for the participant to have nasal swab performed.

Treatment and study plan

Primary outcomes

Identification of influenza A virus infections occurring due to swinevariant influenza

Time frame: Ongoing

Sponsors and collaborators

Lead sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

Nih

Collaborators

Ohio State University

Registry information

Important dates

Study start: 2014
Primary completion: 2019
Study completion: 2019
First posted: Apr 28, 2014
Registry last updated: Jun 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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