Yeast Protein for Muscle Mass

This is a double-blinded randomized clinical trial of a 16-week nutrition intervention with yeast and whey protein in 72 people (36 per group; 18 male and 18 female) between the ages of 18 and 35, recruited from the University of Alberta campus, Edmonton, Canada. Consenting participants will be randomly assigned to one of two groups: whey protein or yeast protein by the study coordinator, who will not collect study outcome measurements or analyze the data.

The goal of the trial is to determine if consumption of 40 g per day of yeast protein produces similar effects to 40 g supplementation with whey protein. It is anticipated that daily yeast protein consumption will show similar gains in muscle mass and improvement in immune function, increased diversity in gut microbiota, and amino acid-derived metabolites compared to whey protein.

Inclusion criteria

• Participants must have the ability to read, understand, and sign an informed consent and must be willing to comply with study treatment and follow-up.
• Prior resistance training experience (defined as performing resistance exercises >1/week for the past 3 months or longer) to enable them to reach a large training stimulus relatively quickly and to avoid the longer phase of neuromuscular adaptations
• ≥18 years and <35 years of age

Exclusion criteria

• Diabetes, musculoskeletal disease, cancer, Crohn's disease, or any other acute or chronic condition that interferes (or the medication prescribed for those conditions) with muscle anabolism.
• Diagnosed with or being treated for heart disease, stroke, high blood pressure 130/80 mmHg or higher
• Pain/discomfort/pressure in the chest during activities of daily living or physical activity
• Pregnant or not on adequate contraception.
• A known hypersensitivity/allergy to ingredients in the supplements.
• Inflammatory bowel diseases
• Enrolment in any other clinical protocol or investigational study that may interfere with study procedures
• Taking antibiotics