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OpenTrials
Completed

NCT Number: NCT03158623

Wound Additives in Primary Total Joint Athroplasty

3 cohorts of total joint patient of 30 members each were randomized to receive PRP or Activated Collegen or no additive were studied for status of the wound at 6 weeks and recorded all complications, infections and reoperations. The three groups were than compared for statistical analysis

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Key information

Conditions

Arthroplasty, Replacement

Age range

50 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

About this study

Background: Wound healing remains a concern in primary total joint arthroplasty given the risk of deep infections arising from hematomas, wound separations, and superficial infections. If wound additives can prevent these early complications, their universal application would be cost effective. This study examined whether two wound additives, Platelet-Rich Plasma (PRP) and CellerateRX® (activated collagen), would improve postoperative wound healing and reduce complications in primary total joint arthroplasty.

Methods: A prospective, randomized, controlled study using three cohorts with 30 patients each (Group 1: PRP, Group 2: activated collagen, Group 3: control) were examined postoperatively at two and six weeks, at which time the following data were recorded: six wound measurements, total postoperative blood loss, complications of superficial infections, and reoperations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Osteoathritis of knee and hip

Exclusion criteria

  • Inflammatory arthritis and hypercoagulable state

Treatment and study plan

Platelet rich plasma

Biological

Other names: PRP

Cellerate

Biological

Other names: Activated college

Primary outcomes

  1. Wound Status

    Time frame: 6 weeks post operative

    wound hematoma, dehiscence, superficial infection

Sponsors and collaborators

Lead sponsor

Salt Lake Orthopedic Clinic

Other

Registry information

Official study title

The Effects of Platelet-Rich Plasma and Activated Collagen on Wound Healing in Primary Total Joint Arthroplasty

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
May 18, 2017
Registry last updated
May 18, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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