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Completed

NCT Number: NCT00430560

Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia

This research investigates the benefits of productive activity and cognitive rehabilitation for patients with schizophrenia. Key questions are:

1. does cognitive rehabilitation plus work activity produce better outcomes than work activity alone? 2. Is cognitive rehabilitation more helpful for individuals with moderate or greater cognitive impairment than for individuals without such impairment? 3. Does cognitive rehabilitation reduce the dropout rate and increase participation in work activity for cognitively impaired subjects? 4. What features of cognitive rehabilitation are most important for clinical and rehabilitation outcomes?

Completed

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Key information

Conditions

Schizophrenia Mental Disorders Psychotic Disorders Schizoaffective Disorder Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

VA Connecticut Healthcare System

West Haven, Connecticut, 06516, United States

About this study

This is a randomized, matching study in which subjects are stratified by degree of cognitive impairment, then randomly assigned to one of two conditions: Work Services Only vs. Work Services plus cognitive rehabilitation. Longitudinal analysis of work activity, work performance, symptoms, quality of life, cognitive function and service utilization are made.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of schizophrenia or schizoaffective disorder

Exclusion criteria

  • change in psychiatric medications or housing within 30 days of study intake
  • episode of drug abuse within 30 days of study intake
  • GAF score 30 or less
  • known neurological disease or developmental disability

Treatment and study plan

Cognitive Rehabilitation

Behavioral

computer training

Other names: computer training

work therapy

Procedure

opportunity to work in carefully supervised hospital job

Other names: IWT

work therapy

Behavioral

work therapy

Primary outcomes

  1. Neuropsychological test performance

    Time frame: data collection completed

Secondary outcomes

  1. Hours of productive activity

    Time frame: data collection completed

  2. Hours worked

    Time frame: data collection completed

  3. Quality of life

    Time frame: data collection completed

  4. Psychiatric symptoms

    Time frame: data collection completed

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Collaborators

  • VA Connecticut Healthcare System

Registry information

Official study title

Work Activity Augmented by Cognitive Rehabilitation: Continuation and Follow-up

Important dates

Study start
2000
Primary completion
2005
Study completion
2015
First posted
Feb 2, 2007
Registry last updated
Sep 11, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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