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Completed

NCT Number: NCT01888276

Words Generation in Compulsives Gamblers and Parkinson's Disease Patients

The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.

Thanks to the words generation test, which reflects the cortico-subcortical loop functioning, involved in motivation, we want to evaluate and compare using tools (words generation and behavioral tests) the motivational functioning of gamblers and healthy volunteers that we can then compare to that of Parkinson's patients with and without behavioral hyperdopaminergic disorders which were explored in another study.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

30 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU toulouse

Toulouse, 31000, France

About this study

The main objective of this study is to evaluate performance during words generation in gamblers and healthy volunteers compare to those of PD patients with and without hyper-dopaminergic behaviors collected during another study.

2 groups of subjects will be recruited for the study: 20 compulsive gamblers and 20 healthy volunteers

Each subject will realize twice each test during 2 sessions with one hour in between :

During the session 1 :

  • The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
  • The test of Stroop that assesses selective attention

During the session 2:

  • The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
  • The task of the casino (Iowa Gambling Test)
  • The task of landing
  • The test of Stroop

We supposed that the performance of compulsive gamblers in words generation test will be higher than those of healthy volunteers, themselves superior to those of PD patients with a hyper-dopaminergic behavior, themselves superior to those of PD patient without hyper-dopaminergic behavior.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For healthy volunteers :

  • Subject from 30 to 75 years old (Male and female)
  • Subject with French mother tongue
  • Subject who give their informed and signed consent.
  • Subject affiliated to a social protection program

For compulsive gamblers :

  • Subject from 30 to 75 years old (Male and female)
  • Subject with French mother tongue
  • Subject with at least 5 criteria of 10 DSM IV diagnostic criteria for pathological gambling
  • Subject who give their informed and signed consent.
  • Subject affiliated to a social protection program

Exclusion criteria

For healthy volunteers and compulsive gamblers :

  • Presence of apathy defined as a score greater or equal to 14 on the scale of Starkstein
  • Presence of severe depression defined as a score greater or equal to 25 on the scale BDI (Beck Depression Inventory)
  • Presence of dementia defined as a score below 25 on the MMSE
  • Subject with vision problems making it impossible for the tests
  • Pregnant women
  • Subject under tutelage, curatelle or law protection
  • Subject included in an other clinical study

Treatment and study plan

evaluation of word generation and of motivation

Other

Each subject will realize twice each test during 2 sessions with one hour in between :

During the session 1 :

  • The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
  • The test of Stroop that assesses selective attention

During the session 2:

  • The test of words generation, which is to produce action verbs in response to 40 nouns, and noun in response to verbs.
  • The task of the casino (Iowa Gambling Test)
  • The task of landing
  • The test of Stroop

Primary outcomes

  1. Changement of number of mistake during the words generation test

    Time frame: one hour

Secondary outcomes

  1. changement of number of uncorrected errors during the Stroop test which reflects the incapacity to inhibit the reading and that evaluates attention

    Time frame: one hour

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Study of Words Generation in Compulsives Gamblers and Healthy Volunteers: Comparison With a Study of Parkinson's Disease Patients

Acronym: FLUENCE

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jun 27, 2013
Registry last updated
Jun 11, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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