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Completed

NCT Number: NCT01488500

Woodsmoke Exposure and Cardiovascular Function

Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract. It is not determined how different types of biomass combustion affect human health. In this study the investigators plan to investigate how inhalation of wood smoke and pellets smoke affect respiratory and cardiovascular health.

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Key information

Conditions

Respiratory Inflammation Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammation

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Umeå University

Umeå, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • Use of regular medication except the oral contraceptive pill
  • Current smokers
  • Significant occupation exposure to air pollution
  • Intercurrent illness

Treatment and study plan

Bronchoscopy

Other

24 hours after exposure, a bronchoscopy will be performed to allow analysis of cells and inflammatory markers in bronchial wash, bronchioalveolar lavage and lung biopsies.

Primary outcomes

  1. Respiratory inflammation

    Time frame: 24 hours after exposure to air or woodsmoke

    Bronchoscopy will be performed, and samples collected by bronchoalveolar lavage and bronchial biopsy. Samples will be analysed for cell counts, histology and inflammatory markers.

Secondary outcomes

  1. Central arterial stiffness

    Time frame: Baseline and for 1 hour after exposure

    Central arterial stiffness will be measured at baseline and for the 1 hour following the exposure using the SphygmoCor and Vicorder devices

  2. Heart rate variability

    Time frame: 24 hours after the exposure

    Continuous electrocardiograms will be recorded using a holter monitor to determine heart rate variability

  3. Systemic inflammation

    Time frame: 24 hours after the exposure

    Blood samples will be taken at intervals following the exposure to woodsmoke to measure circulating inflammatory markers

  4. Lung function

    Time frame: Baseline and 24hrs after exposure

    Lung function will be assessed using spirometry before and after each exposure

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • Umeå University

Registry information

Official study title

Cardiovascular Effects of Experimental Exposure to Woodsmoke in Man

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Dec 8, 2011
Registry last updated
Aug 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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