Women With Migraine With Aura Neuroimaging Study

The purpose of this study is to investigate whether a particular form of migraine, migraine with aura, is associated with structural changes in the brain

Completed

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Key information

Conditions

Migraine With Aura Brain Diseases Central Nervous System Diseases Headache Disorders Headache Disorders, Primary Migraine Disorders Nervous System Diseases

Age range

30 year–60 year

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

female
case (migraine with aura), co-twin to case, or control (migraine-free)
residency in Denmark
no severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders

Exclusion criteria

male
residency outside Denmark
registered in Civil Registry as not to be contacted by researchers
severe neurological (vascular, neurodegenerative or neuroinflammatory) disorders, or other somatic or psychiatric disorders
mobile metal parts or other contraindication for MRI
weight of 130+ kilograms
pregnancy
subjects that wished not to be informed about abnormal findings on MRI
chronic tension-type headache, medication overuse headache, or cluster headache (diagnosed through physician interview)
frequent tension-type headache (control group only, self-reported or diagnosed through physician interview)

Treatment and study plan

Primary outcomes

Evidence of white matter hyperintensities or subclinical ischaemic stroke confirmed by MRI

Time frame: At time of MRI

Secondary outcomes

Evidence of other structural and functional changes in brain

Time frame: At time of MRI

Sponsors and collaborators

Lead sponsor

Odense University Hospital

Other

Collaborators

Copenhagen University Hospital, Hvidovre
Glostrup University Hospital, Copenhagen
University of Southern Denmark

Registry information

Official study title

Women With Migraine With Aura Neuroimaging (WOMAN) Study: A Population-based Study of Danish Twins

Acronym: WOMAN

Important dates

Study start: 2011
Primary completion: 2015
Study completion: 2017
First posted: Jan 28, 2014
Registry last updated: Apr 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed