Wine Consumption and Glycemic Control

Many studies have reported that alcoholic beverage consumption, especially in the form of wine, reduces the risk of developing type 2 diabetes by as much as 40%. This association suggests that wine consumption may somehow improve the body's ability to control its blood glucose concentration. Indeed, it has been reported that when wine is consumed immediately prior to ingestion of glucose, the release of insulin is enhanced and blood glucose concentration is lowered. The mechanism of wine's effects on blood glucose concentration is unknown, but is likely related to its ethanol or antioxidant content. In this study, the investigators plan to test whether wine or plain ethanol (vodka) ingestion alters the control of blood glucose in subjects who have diabetes or pre-diabetes.

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Key information

Conditions

Diabetes Mellitus, Type 2 Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Missouri

Columbia, Missouri, 65202, United States

About this study

Our central hypothesis is that improvement in glycemic control by acute consumption of wine is mediated by ethanol. Subjects will have type 2 diabetes, pre-diabetes, and be sedentary and obese (BMI >30). Subjects' glycemic control will be assessed by an oral glucose tolerance test (OGTT) at three different time points. One OGTT will occur shortly after consumption of red wine, the second after consumption of vodka containing the identical amount of ethanol as the wine treatment, and the third OGTT will occur shortly after consumption of an equal volume of water. The three OGTTs will be administered in random order.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

insulin resistant: diagnosed with pre-diabetes or fasting blood glucose >/= 97 mg/dL
T2D: diagnosed by primary care physician
at risk of type 2 diabetes (obesity and physically inactive)
age: 21-65

Exclusion criteria

smoking
insulin use (other than once daily)
physically active (>30 mins aerobic exercise two days/week)
recent (>3 mo) changes in medication use or dose
uncontrolled type two diabetes (HbA1C >10%)
advanced retinopathy or neuropathy
pregnancy

Treatment and study plan

Alcohol consumption

Other

28 grams (2 drinks) of ethanol will be consumed either in the form of wine or vodka.

Primary outcomes

Oral glucose tolerance test

Time frame: 3 weeks

Measurement of blood glucose taken every 15 minutes over a course of three hours.

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Acronym: WGC

Important dates

Study start: 2012
Primary completion: 2015
Study completion: 2015
First posted: Aug 7, 2015
Registry last updated: Oct 26, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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