Will Erectile Dysfunction Increase the Risk of Prostate Cancer

The rationale for investigating the hypothesis that there is an association between erectile dysfunction (ED) and the subsequent development of prostate cancer is based on three assumptions: 1) baseline ED is common in most if not all of the cross-sectional studies in men with prostate cancer; 2) the development of ED and prostate cancer may have certain shared common risk factors; and 3) the use of testosterone for the treatment of ED has been suspected to be associated with prostate cancer development. Controversy exists over whether men with ED have an increased risk of subsequent prostate cancer. Few studies have evaluated the risk of developing prostate cancer for men with ED. The investigators, therefore, conducted a population-based longitudinal study with eight years' follow-up to examine this association and to evaluate the magnitude of the risk.

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Key information

Conditions

Erectile Dysfunction Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Mental Disorders Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Hyperplasia Prostatic Neoplasms Sexual Dysfunction, Physiological Sexual Dysfunctions, Psychological Urogenital Diseases Urogenital Neoplasms

Age range

50 year–99 year

Sex eligibility

Male

Study type

Observational

Primary location

Kuang Tien General Hospital

Taichung, 43303, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

men 50 years and older with no pre-existing prostate cancer

Exclusion criteria

less than 50 years old
pre-existing prostate cancer

Treatment and study plan

Erectile dysfunction

Other

Patients with ED are considered belonging to the exposure group.

Primary outcomes

Incident prostate cancer

Time frame: through study completion, up to 7 years

Sponsors and collaborators

Lead sponsor

Kuang Tien General Hospital

Other

Collaborators

Asia University
National Central University, Taiwan

Registry information

Official study title

Erectile Dysfunction and the Future Risk of Prostate Cancer: a Population-based Longitudinal Follow-up Study With Concurrent Double Comparison Cohorts

Acronym: EDtoPC

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Jan 4, 2017
Registry last updated: May 9, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed