Will Adjusting the pH of Lidocaine Reduce the Pain During Injection of Local Anaesthetic?

This study will investigate the influence of adjusting the pH of lidocaine on pain during subcutaneous injection. Each participant will receive two injections on the abdomen with different pH. After each injection, the subject will be asked to evaluate the pain on a Visual analog scale (0-100 mm). It is anticipated that the pain decreases with increasing pH. The aim of the study is to find a simple method for pain reduction that can be used in clinical practice.

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Key information

Conditions

Needlestick Injuries Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Wounds and Injuries Wounds, Penetrating Wounds, Stab

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Neuroscience, NTNU

Trondheim, Norway

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

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Age 18-65 years

Exclusion criteria

Kidney, heart or liver disease
Eczema or psoriasis on injection site
Neuropathy
Regular use of painkillers
Hypersensitivity of Lidocaine
Pregnancy
Diabetes

Treatment and study plan

Lidocaine injection with bicarbonate

Procedure

bicarbonate added to change pH

Lidocaine Injection

Procedure

Lidocaine injection with pH unchanged

Primary outcomes

Pain

Time frame: 60 seconds
- Visual Analog Scale 0-100 mm
- Questionnaire

Sponsors and collaborators

Lead sponsor

Norwegian University of Science and Technology

Other

Collaborators

St. Olavs Hospital

Registry information

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2014
First posted: Apr 8, 2014
Registry last updated: May 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed