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Completed

NCT Number: NCT03647787

White Matter Integrity According to BDNF Genotype After Stroke

The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center

Seoul, Gangnam-gu, 06351, South Korea

About this study

The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the intrahemispheric connection from M1 to ventral premotor cortex (M1PMv), and the other is the interhemispheric connection between bilateral M1s (CC). There were also to investigate the relationships between motor impairment and tract-related FA of white matter tracts in each BDNF genotype

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed with first-ever hemispheric ischemic infarction with damage to the supratentorial area confirmed by brain MRI within 2 weeks after stroke onset

Exclusion criteria

  • any clinically significant or unstable medical disorder or neuropsychiatric comorbidity

Treatment and study plan

observational study

Other

This study is a longitudinal observational study

Primary outcomes

  1. Fractional anisotropy

    Time frame: 2 weeks to 3 months after stroke onset

    changes of fractional anisotropy (FA) in the corticospinal tract (CST)

Secondary outcomes

  1. Fractional anisotropy

    Time frame: 2 weeks to 3 months after stroke onset

    changes of fractional anisotropy (FA) in the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv)

  2. Fractional anisotropy

    Time frame: 2 weeks to 3 months after stroke onset

    changes of fractional anisotropy (FA) in the corpus callosum (CC)

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Aug 27, 2018
Registry last updated
Sep 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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