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OpenTrials
Completed

NCT Number: NCT00391235

White Matter in Pediatric Bipolar Disorder: A DTI Study

Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.

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Key information

Conditions

Bipolar Disorder Bipolar and Related Disorders Mental Disorders Mood Disorders

Age range

6 year–13 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Cambridge Health Alliance

Medford, Massachusetts, 02155, United States

About this study

We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 6 to 13
  • Male or female
  • Right-handed

Exclusion criteria

  • IQ less than 70
  • Learning disabilities
  • History of autism, schizophrenia, anorexia or bulimia nervosa
  • Substance abuse
  • Claustrophobia
  • Metal in body
  • Pregnancy or lactation

Treatment and study plan

Primary outcomes

  1. Fractional anisotropy in brain white matter

    Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Cambridge Health Alliance

Other

Collaborators

  • American Academy of Child Adolescent Psychiatry.
  • Eli Lilly and Company

Registry information

Official study title

White Matter Connectivity in Pediatric Bipolar Disorder: A Diffusion Tensor Imaging Study

Important dates

Study start
2005
Primary completion
2008
Study completion
2008
First posted
Oct 23, 2006
Registry last updated
Dec 6, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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