White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke.

The aim of this study was to investigate the role of Neutrophil-to-Lymphocyte Ratio (NLR) and other derived white cell markers as early markers of delirium and outcome after acute ischemic stroke (AIS).

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Key information

Conditions

Delirium Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Confusion Ischemic Stroke Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Delirium is an acute brain disorder, potentially reversible, commonly occurring in patients with acute ischemic stroke. The pathomechanism of delirium is related to neuroinflammatory process and oxidative stress. Search for readily available diagnostic marker that will aid clinicians in early identification of delirium is an on-going process. The aim of this study was to investigate the role of Neutrophil-to-Lymphocyte Ratio (NLR) and other derived white cell markers as early markers of delirium and outcome after acute ischemic stroke (AIS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age >18 years)
acute ischemic stroke

Exclusion criteria

hematology disorders
incomplete laboratory testing
no data regarding follow-up

Treatment and study plan

Delirium assessment.

Diagnostic Test

Full blood count analysis.

Primary outcomes

Early-onset-delirium.

Time frame: 24 hours

Delirium within 24 hours from admission.

Secondary outcomes

Mortality at 30 days.

Time frame: 30 days

Mortality determined at follow-up on day 30 after acute ischemic stroke.
Mortality at 1 year.

Time frame: 1 year

Mortality determined at follow-up at 1 year after acute ischemic stroke.

Sponsors and collaborators

Lead sponsor

Pomeranian Medical University Szczecin

Other

Registry information

Official study title

White Cell Ratios as Markers of Delirium and Outcome in Acute Ischemic Stroke. DELirium in Acute Ischemic Stroke [DELIAS]

Acronym: DELIAS

Important dates

Study start: 2015
Primary completion: 2019
Study completion: 2019
First posted: May 9, 2019
Registry last updated: May 10, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed