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NCT Number: NCT06106555

Which Factors Are Relevant for Treatment Outcome in Dialectical Behaviour Therapy for Borderline Personality Disorder?

The objective of this project is to investigate factors that contribute to the success and lack of success in DBT among individuals with BPD and a history of self-harm in a clinical psychiatric setting.

1. Do certain personality factors and identity disturbance predict the treatment outcome of DBT in individuals with BPD? 2. Do changes in identity disturbance, self-hate, or emotion regulation mediate the treatment outcome of DBT in individuals with BPD? 3. Do specific personality profiles moderate the treatment outcomes of DBT for individuals with BPD? 4. When does the primary treatment effect occur, and does this effect persist after a 12-month follow-up period?

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Lund adult psychiatric hospital

Lund, Skåne County, 22185, Sweden

Location status: Recruiting

Location contact

Magnus Nilsson, PhD

CONTACT

[email protected]

046174925

About this study

Borderline Personality Disorder (BPD) is a complex and enduring mental health condition characterized by a range of symptoms. The consequences of BPD are severe, causing individual suffering, impairments in daily functioning, and increased mortality rates. Dialectical behavior therapy (DBT) is one of the most widely used treatment models for BPD and self-harm. DBT has demonstrated positive outcomes but not all individuals benefit equally from this therapy, highlighting the need for further exploration. Specifically, there is a knowledge gap regarding what predicts positive treatment response. Research exploring this topic, has highlighted the potential significance of emotion regulation, personality profiles, self-concept, and identity disturbance in understanding the outcomes of individuals with BPD.

The primary objective of this research project is to investigate the factors that contribute to the success and lack of success in DBT.

All individuals referred to DBT-treatment in the Adult psychiatric clinic in Lund will be offered participation in the study. All study participants receive the same treatment as those who chose not to participate. Measures will commence after treatment contracts have been negotiated and the treatment will continue up to a maximum treatment length of one year.

Data will be retrieved from databases, medical records as well as collected as self-report forms. Self-report measures will be conducted every three months, at end of treatment and at follow up 12 months after end of treatment. Data from registries and charts will be collected at time of consent and at follow up 12 months after treatment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Borderline personality disorder as defined by the DSM-V (assessed with SCID or uquivalent).
  • Self-harm over the past 12 months
  • Offered DBT at the Lund adult psychiatric clinic

Exclusion criteria

  • Unable to read or communicate in Swedish

Treatment and study plan

Dialectibal Behaviour Therapy

Behavioral

Standard Dialectical Behaviour Therapy of up to 12 months as described Professor Linehan

Primary outcomes

  1. Five Self-harm Behaviour Groupings Measure (5S-HM)

    Time frame: Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

    Indirect and direct self-harm

Secondary outcomes

  1. The World Health Organization Disability Assessment Schedule II (WHODAS 2)

    Time frame: Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

    Daily functioning and impairment

  2. The Borderline Symptom List-23 (BSL-23)

    Time frame: Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

    Borderline symptoms

  3. The Level of Personality Functioning Scale-Brief Form 2.0 (LPFS 2.0)

    Time frame: Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

    Personality functioning

  4. The Personality Inventory for DSM-V Brief Form (PID-5-BF)

    Time frame: Treatment start, 3,6,9 and at end of treatment and at follow up at 24 months.

    Personality structure

  5. Hospitilization days

    Time frame: Treatment at end of treatment and at follow up at 24 months.

    Days admitted to a psychiatric ward past year

Study contacts

Contact information is provided by the study sponsor or research team.

Magnus Nilsson, PhD

CONTACT

[email protected]

046174925

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Collaborators

  • Department of Psychology. Lund University.
  • Lund University
  • University of Toronto

Registry information

Official study title

Vilka Faktorer påverkar Behandlingsutfall Vid Dialektisk Beteendeterapi för Borderline Personlighetssyndrom?

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Oct 30, 2023
Registry last updated
Jun 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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