When and How to Administer Oxytocin for Active Management of Third Stage of Labour

To compare the efficacy of the route and timing of oxytocin administration for Active management of third stage of labour (AMTSL).

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Key information

Conditions

Postpartum Bleeding Female Urogenital Diseases and Pregnancy Complications Hemorrhage Obstetric Labor Complications Pathologic Processes Pathological Conditions, Signs and Symptoms Postpartum Hemorrhage Pregnancy Complications Puerperal Disorders Urogenital Diseases Uterine Hemorrhage

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital

Ankara, Turkey (Türkiye)

About this study

Our objective is to determine the most efficient route and timing of oxytocin administration by measuring the duration of third stage of labour, quantitative blood during the first hour after delivery and comparing haemoglobin and haematocrit changes and the need for additional interventions in patients who had either a spontaneous labour or received labour augmentation with oxytocin.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

having a singleton pregnancy above 37th gestational week
normal live vaginal delivery with cephalic presentation
being in active labor

Exclusion criteria

Fetal demise
multiple pregnancy
known coagulation disorder
presentation anomalies
placental pathology
liver disease
thrombocytopenia
hypertension or being currently on anticoagulants
having a cesarean section, operative delivery or deep vaginal tear
chorioamnionitis
developing HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) or DIC (disseminated intravascular coagulation) before delivery

Treatment and study plan

intravenous & intramuscular oxytocin

Drug

intravenous or intramuscular 10 iu oxytocin

Other names: Postuitrin

after delivery of the fetus & when anterior shoulder seen

Procedure

oxytocin 10 iu after the delivery of the fetus or when the anterior shoulder was seen after the fetal head was delivered

Primary outcomes

postpartum bleeding in the third stage of labour

Time frame: participants will be followed for the duration of hospital stay, an expected average of 48 hours

Sponsors and collaborators

Lead sponsor

Etlik Zubeyde Hanim Womens' Health and Teaching Hospital

Unknown

Registry information

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: Oct 1, 2013
Registry last updated: Oct 1, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed