Weight Fluctuation After Breast Cancer Treatment

This study aims to identify and quantify the factors associated with excess weight gain following treatment for breast cancer. It is believed that breast cancer patients gain more than 4% of their weight at diagnosis which is likely accompanied by an increase in body fat and waist circumference. It is further thought that this excess weight and increase in body fat and waist circumference are associated to tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity. It is also thought that women treated with chemotherapy have higher levels of glucose and insulin.

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Key information

Conditions

Breast Cancer Body Weight Body Weight Changes Breast Diseases Breast Neoplasms Neoplasms Neoplasms by Site Pathological Conditions, Signs and Symptoms Signs and Symptoms Skin Diseases Skin and Connective Tissue Diseases Weight Gain

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Females 18 years of age or older.
Diagnosed with breast cancer between 1/1/2003 and 31/12/2007.
Able to understand and willing to sign informed consent.

Exclusion criteria

Known diagnosis of previous breast/other cancer (other than completely resected non-melanoma skin cancer or successfully treated in situ cancer of the cervix.
Known diagnosis of inflammatory bowel disease or malabsorption syndrome.
Known diagnosis of endocrine problems associated with the development of obesity (cushings syndrome, hypo/hyperthyroid, thyroiditis)
Treatment for psychiatric disorders.

Treatment and study plan

Fasting blood sample.

Procedure

Fasting blood sample taken following informed consent for genotyping, glucose and insulin levels.

Primary outcomes

To provide evidence of the relationship between weight gain following diagnosis of breast cancer and tumour characteristics, chemotherapy, menopause status at diagnosis and the presence of genes related to obesity.

Time frame: 12-18 months.

Sponsors and collaborators

Lead sponsor

The Royal Bournemouth Hospital

Other

Registry information

Important dates

Study start: 2008
Primary completion: 2013
First posted: Oct 8, 2009
Registry last updated: Sep 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed