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OpenTrials
Completed

NCT Number: NCT07712237

Web-Based Advance Care Planning for Patients With Advanced Cancer

The goal of this clinical trial is to determine whether a web-based advance care planning (ACP) intervention can reduce preferences for aggressive life-sustaining treatments among patients with advanced cancer.

The main questions it aims to answer are:

* Does a web-based ACP intervention reduce preferences for aggressive life-sustaining treatments among patients with advanced cancer? * Does a web-based ACP intervention support informed medical decision-making regarding future care?

Researchers will compare a web-based ACP intervention plus a Patient Right to Autonomy Act leaflet with a Patient Right to Autonomy Act leaflet alone to determine whether the web-based ACP intervention is more effective in reducing preferences for aggressive life-sustaining treatments.

Participants will:

* Be randomly assigned to either an intervention group or a control group * Receive either a web-based ACP educational program plus a Patient Right to Autonomy Act leaflet, or a Patient Right to Autonomy Act leaflet alone * Complete questionnaires at baseline, immediately after the intervention, and one week after the intervention

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Tri-Service General Hospital

Taipei, Taipei City, Taiwan

About this study

Advance care planning (ACP) is a process that enables individuals to understand and communicate their values, goals, and preferences regarding future medical care. ACP is particularly important for patients with advanced cancer, who may face complex decisions regarding life-sustaining treatments and end-of-life care. However, ACP participation remains limited, and innovative approaches are needed to improve patient engagement.

This study was designed to evaluate the effectiveness of a web-based ACP intervention in reducing preferences for aggressive life-sustaining treatments among patients with advanced cancer. The intervention was developed to provide accessible ACP education and information regarding the Patient Right to Autonomy Act in Taiwan.

A single-blind randomized controlled trial design was used. A total of 110 patients with stage III or IV cancer were recruited and randomly assigned to either an intervention group (n = 55) or a control group (n = 55). Participants in the intervention group received a web-based ACP educational program in addition to a Patient Right to Autonomy Act leaflet, whereas participants in the control group received the leaflet alone.

Outcome assessments were conducted at baseline (T1), immediately after the intervention (T2), and one week after the intervention (T3). The primary objective was to determine whether the web-based ACP intervention reduced preferences for aggressive life-sustaining treatments. The study also examined factors associated with treatment preferences and medical decision-making.

The findings of this study may contribute to the development of accessible ACP interventions and support informed decision-making among patients with advanced cancer.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Diagnosed with advanced cancer (stage III or IV)
  • Aged 18 years or older
  • Able to communicate fluently in Mandarin Chinese or Taiwanese
  • Able and willing to provide informed consent
  • No cognitive impairment
  • Have access to Internet-connected electronic devices at home
  • Have not previously received advance care planning (ACP) consultation
  • Have not completed an advance directive (AD)

Exclusion criteria

  • No access to Internet-connected electronic devices at home
  • Unable to operate Internet-based electronic devices
  • Previous participation in ACP consultation or completion of an AD
  • Cognitive impairment
  • Severe physical or psychological symptoms that would interfere with participation in the study
  • Concurrent participation in another intervention study
  • Refusal to participate

Treatment and study plan

Web-Based Advance Care Planning Program

Behavioral

A web-based educational program designed to improve advance care planning knowledge, promote informed decision-making, and facilitate discussions regarding future medical care among patients with advanced cancer.

Patient Right to Autonomy Act Leaflet

Other

An educational leaflet providing information about the Patient Right to Autonomy Act and advance care planning.

Primary outcomes

  1. Change in Preference for Aggressive Life-Sustaining Treatments

    Time frame: Baseline and 1 Week After Intervention

    Preferences for aggressive life-sustaining treatments were assessed using the Life-Sustaining Treatment Preference Questionnaire. Higher scores indicate stronger preferences for aggressive life-sustaining treatments. Changes from baseline were compared between the intervention and control groups.

Sponsors and collaborators

Lead sponsor

Tri-Service General Hospital (TSGH)

Other

Registry information

Official study title

A Web-Based Advance Care Planning Intervention to Reduce Preferences for Aggressive Life-Sustaining Treatments in Patients With Advanced Cancer: A Randomized Controlled Trial

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jul 17, 2026
Registry last updated
Jul 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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