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NCT Number: NCT06542107

Weaning From Mechanical Ventilation in Patients With Acute Brain Injury

Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and weaning. However, the rate of extubation failure was significantly higher in ABI patients compared with non-neurological critical care patients. In patients who have failed one or several trials of extubation, tracheostomy is recommend according to the latest ESICM consensus. Tracheostomy can enhance comfort, improve pulmonary hygiene and decrease sedation requirement, which could facilitate the liberation from ventilator.

Numerous studies have explored the causes of weaning failure and provide various predictive models in guiding extubation and tracheostomy. Yet, due to limitations of such as small sample size or a lack of external validation, there is paucity of practical weaning algorithm tailored for ABI patients. The liberation from IMV in ABI patients still remains challenging with poor level of evidence in current guidelines or expert consensus.

We aim to describe the weaning outcomes in ABI patients, and further investigate the potential predictors of weaning success in ABI patients.

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Key information

Conditions

Ventilator Lung Acute Brain Injury Brain Diseases Brain Injuries Central Nervous System Diseases Craniocerebral Trauma Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ling Liu, Nanjing, Jiangsu, China

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Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • acute brain injury
  • age >=18 years
  • invasive mechanical ventilation for at least 24 hours

Exclusion criteria

  • tracheostomized before ICU admission
  • pregnant or lactation
  • with cervical spinal cord injury
  • decision to receive palliative care within 24 hours of ICU admission

Treatment and study plan

Primary outcomes

  1. weaning success

    Time frame: up to 7-day period (ICU stay)

    successfully weaned from invasive ventilation according to WIND classification

Secondary outcomes

  1. extubation

    Time frame: up to 7-day period (ICU stay)

    Extubation without the need for reintubation or death within a 7-day period, or upon ICU discharge, whichever occurs first

Other outcomes

  1. tracheostomy

    Time frame: up to 7-day period (ICU stay)

    tracheostomy during ICU stay

Study contacts

Contact information is provided by the study sponsor or research team.

Ling Liu, PHD

CONTACT

[email protected]

86+83262553

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Prediction of Weaning for Patients With Acute Brain Injury Undergoing Mechanical Ventilation

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 7, 2024
Registry last updated
Nov 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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