Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Istanbul, 34186, Turkey (Türkiye)
NCT Number: NCT07170709
This study aims to investigate how the magnitude of mechanical loading affects reflex latency patterns induced by whole-body vibration (WBV). WBV can trigger two types of reflexes: the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR), which may be influenced by load-bearing condition. The study will include healthy adult volunteers aged 20-50 years. Reflex responses will be recorded from the soleus muscle using surface EMG during both WBV. Different conditions of mechanical loading (i.e., standing on one foot, both feet) and vibration frequencies (30-36 Hz) will be tested. The main outcome will be the latency of the reflex responses, which will help distinguish between TVR and BMR activation. The goal is to better understand how mechanical load modifies reflex response timing and to characterize the underlying afferent pathways. This knowledge may contribute to optimizing vibration-based rehabilitation strategies.
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Notify Me18 year–45 year
All sexes
Interventional
Not applicable
Istanbul, 34186, Turkey (Türkiye)
This study investigates how the magnitude of mechanical loading alters reflex latency patterns during whole-body vibration (WBV), focusing specifically on the tonic vibration reflex (TVR) and the bone myoregulation reflex (BMR). Experimental data suggest that WBV may activate different reflex mechanisms depending on the level of postural loading, frequency, and amplitude of the vibration. Previous studies have shown that low-amplitude WBV tends to activate TVR under voluntary contraction, while higher mechanical loads and neutral standing posture are more likely to induce BMR.
Surface electromyography (sEMG) recordings will be obtained from the soleus muscle during vibration stimuli applied at different frequencies (30, 32, 34, and 36 Hz). Recordings will be taken under multiple loading conditions: standing on both feet, standing on one foot. Reflex latency will be calculated using cumulative averaging techniques, and data will be analyzed offline using Spike2 software.
Findings from this study may contribute to a deeper understanding of reflex integration during vibratory stimulation and inform future neurorehabilitation protocols that utilize WBV as a therapeutic modality.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Participants will receive whole-body vibration (WBV) at 30-36 Hz under different mechanical loading conditions (e.g., standing on one foot, both feet,). Vibration-induced reflex responses will be recorded from the soleus muscle using surface electromyography. The intervention is designed to evaluate latency differences between tonic vibration reflex (TVR) and bone myoregulation reflex (BMR) under controlled biomechanical scenarios.
Other names: WBV, Reflex Latency Vibration Protocol
Time frame: Day 1 (single-session, during each experimental condition)
Reflex latency will be calculated based on surface EMG recordings from the soleus muscle during whole-body vibration at frequencies of 30-36 Hz. Latency will be analyzed using cumulative averaging techniques and expressed in milliseconds.
Time frame: Day 1 (single-session, during each experimental condition)
The magnitude of EMG response during whole-body vibration will be recorded from the soleus muscle. Reflex amplitude differences will be analyzed across various postural loading conditions to evaluate suppression or facilitation effects.
Time frame: Day 1 (single-session, during each experimental condition)
Reflex responses will be categorized as tonic vibration reflex (TVR) or bone myoregulation reflex (BMR) based on latency values and mechanical loading condition. Classification will be supported by comparisons of reflex latency and EMG suppression patterns across experimental conditions.
Time frame: Day 1 (single-session, during each experimental condition)
Variability in reflex latency will be assessed across different postural load conditions (e.g., single-leg, double-leg, prone) to determine how load magnitude influences the consistency of reflex timing. Standard deviation and coefficient of variation will be calculated for each condition.
Time frame: Day 1 (single-session, during each experimental condition)
Reflex latency and EMG amplitude will be compared across vibration frequencies (30, 32, 34, and 36 Hz) to investigate frequency-dependent modulation of neuromuscular responses in the soleus muscle.
Selim Sezikli
Other Gov
Effect of Mechanical Load Magnitude on Reflex Latency Induced by Whole-Body Vibration: A Latency-Based Evaluation of Bone Myoregulation Reflex and Tonic Vibration Reflex
Acronym: WBV-BMR
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