Universidade Federal do Rio de Janeiro
Macaé, Rio de Janeiro, 27979-000, Brazil
NCT Number: NCT04781595
Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.
Looking for future studies?
Notify Me18 year–85 year
All sexes
Interventional
Not applicable
Macaé, Rio de Janeiro, 27979-000, Brazil
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
for healthy young participants:
Inclusion criteria
for older people with cardiovascular risk:
Exclusion criteria
A single dose of watermelon powder containing 3g of L-citrulline
A single dose of beetroot powder containing 8 mmol of nitrate
A single dose of watermelon and beetroot powder containing 3g of L-citrulline and 8 mmol of nitrate
A single dose of maltodextrin
Time frame: This measure will be evaluate before the nutritional intervention
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Time frame: This measure will be evaluate before the nutritional intervention
Time frame: This measure will be evaluate 30 minutes after the nutritional intervention
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Time frame: This measure will be evaluate 90 minutes after the nutritional intervention
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Time frame: This measure will be evaluate before the nutritional intervention
Time frame: This measure will be evaluate 30 minutes after the nutritional intervention
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Time frame: This measure will be evaluate 90 minutes after the nutritional intervention
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Time frame: This measure will be evaluate before the nutritional intervention
Time frame: This measure will be evaluate 30 min after the nutritional intervention
Time frame: This measure will be evaluate 60 min after the nutritional intervention
Time frame: This measure will be evaluate 90 min after the nutritional intervention
Time frame: This measure will be evaluate 120 min after the nutritional intervention
Time frame: This measure will be evaluate before the nutritional intervention
Time frame: This measure will be evaluate 30 min after the nutritional intervention
Time frame: This measure will be evaluate 60 min after the nutritional intervention
Time frame: This measure will be evaluate 90 min after the nutritional intervention
Time frame: This measure will be evaluate 120 min after the nutritional intervention
Universidade Federal do Rio de Janeiro
Other
Effect of Watermelon and Beetroot Products on Endothelial Function in Young and Older Adults
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT03536871
Atrophy, Healthy Elderly
Hamilton, Ontario, Canada
View Trial DetailsNCT03796117
Electric Stimulation Therapy, Fatigue
Porto Alegre, Rio Grande do Sul, Brazil
View Trial DetailsNCT02764749
Healthy Young
Düsseldorf, Germany
View Trial DetailsNCT04205279
Brain Diseases, Cardiovascular Diseases
Chicago, Illinois, United States
View Trial Details