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OpenTrials
Completed

NCT Number: NCT02373657

Water Uptake for Health in Amhara Pilot

Trachoma is a blinding disease caused by ocular strains of Chlamydia trachomatis. The Carter Center and Proctor Foundation have been jointly conducting trachoma research in the Goncha Siso Enese woreda of Amhara for the past 8 years, through a series of clinical trials. We have found that repeated mass administration of oral azithromycin can greatly reduce the prevalence of trachoma, but mass antibiotics have been unable thus far to eliminate infection. The World Health Organization recommends not only antibiotics for control of trachoma, but an entire SAFE strategy (Surgery for in-turned eyelids, Antibiotics, Facial hygiene promotion, and Environmental improvements such as latrines and water points). Trachoma is more common in villages and households with poor access to water and latrines, so improving the public health infrastructure is thought to be important for limiting transmission of trachoma. However, there is very little evidence to support the efficacy of installing new water points for trachoma. There has been only one previous attempt to study the role of hand dug well installation for trachoma control, and this study, conducted in Niger, found that installing wells was not effective. We now propose a project to improve the public health infrastructure of Goncha Siso Enese woreda by helping with the construction of water points (e.g., hand-dug wells) and providing hygiene education, in order to determine whether improving access to water and hygiene information will be effective for control of trachoma and soil-transmitted helminths.

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Key information

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All residents residing in the state-teams which are randomly selected for this study.

Exclusion criteria

  • Refusal of village chief (for village inclusion), or refusal of parent or guardian (for individual inclusion)

Treatment and study plan

instruction in soap-making and hygiene education

Behavioral

Primary outcomes

  1. Prevalence of ocular chlamydia infection (0-5 year olds)

    Time frame: 24 months

  2. Nasopharyngeal macrolide resistance (0-5 year olds)

    Time frame: 24 months

  3. Prevalence of soil transmitted helminths (Ascaris, Trichuris trichiura, and hookworm) (0-5 year olds)

    Time frame: 24 months

Secondary outcomes

  1. Childhood growth (weight controlled for height among children aged 0-5 years at baseline)

    Time frame: 24 months

  2. Clinically active trachoma in children aged 0-5, as determined by the WHO simplified grading system

    Time frame: 24 months

  3. Prevalence of enteric viruses using PCR (0-5 year olds)

    Time frame: 24 months

  4. Self report childhood morbidity

    Time frame: 24 months

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Acronym: WUHA

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Feb 27, 2015
Registry last updated
Jun 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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