St Mark's Hospital
Harrow, United Kingdom
NCT Number: NCT04710706
The colonoscopy procedure involves insertion of a thin, flexible tube with a tiny camera inside (colonoscope) passed inside the bowel. To allow passage of the colonoscope and adequate visualisation of the lining of the bowel wall a range of techniques can be used. During colonoscopy, you can distend the colon with water, CO2 and air.
Air is no longer recommended for gas insufflation during colonoscopy as it causes pain and excess bowel distention. So the options are water and/or CO2 but it is not entirely clear which combination is the best and at what point during the colonoscopy.
In practice, a hybrid technique where both CO2 and water are used during the colonoscopy in used. Here, water is exclusively used to help navigate the sigmoid colon with air pockets suctioned and turbid water exchanged with clean water. From splenic flexure to caecum a mixture of water and CO2 is used.
The aim of this study is to assess procedure comfort and efficiency of two different colonoscopy insertion techniques: water-alone insertion of the colonoscope (gas insufflation not allowed on insertion; water exchange technique) versus water-CO2 hybrid insertion (water used predominately to splenic flexure with water/CO2 used to caecum; modified water immersion technique).
Looking for future studies?
Notify Me18 year and older
All sexes
Interventional
Not applicable
Harrow, United Kingdom
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Each arm is using a different colonoscopy insertion technique: either water-alone colonoscopy or water-CO2 colonoscopy.
Time frame: During procedure
Time taken to insert the colonoscope
Time frame: During procedure
Time taken to insert and withdraw the colonoscope
Time frame: During procedure
The proportion of procedures where the caecum is reached
Time frame: Immediately after procedure
Patients will subjectively assess discomfort scores following the procedure using a Visual Analogue Scale (VAS) which ranges from 0 to 10 where a higher score means a worse outcome.
Time frame: During procedure
Scopeguide appearance will be used to evaluate number of loops formed
Time frame: 1 week after procedure with results of histology
A measure of the number of adenomas detected during colonoscopy
Time frame: 1 week after procedure with results of histology
A measure of the number of serrated polyps detected during colonoscopy
Time frame: During procedure
The number of patient repositions and abdominal pressure episodes required during the procedure
London North West Healthcare NHS Trust
Other
Water-only Versus Water-CO2 (Hybrid) Colonoscopy Insertion Technique (WAVE): a Randomised Study
Acronym: WAVE
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT04369053
Adenoma, Colon Cancer
Birmingham, Alabama, United States
View Trial DetailsNCT07108569
Colon Polyp, Colonic Adenoma
Würzburg, Germany
View Trial DetailsNCT06345105
Artificial Intelligence, Colon Adenoma
Hong Kong
View Trial DetailsNCT05405530
Colon Cancer, Colon Polyp
Zhengzhou, Henan, China
View Trial Details