NCT Number: NCT01633333
Colonoscopy is commonly used in screening for colorectal cancer. A refined technique of colonoscopy involving the use of water as the sole modality to aid colonoscope insertion, water exchange, has been described in recent research papers to decrease patient discomfort and pain, and to reduce the need for sedation during colonoscopy when compared with standard air insufflation. Carbon dioxide insufflation has been described to decrease patient discomfort after colonoscopy. No randomized trial has so far compared the use of water exchange to carbon dioxide insufflation. Our hypothesis is that water exchange inflicts less discomfort to patients undergoing colonoscopy than carbon dioxide insufflation. Patients undergoing screening colonoscopy in two centers in Norway, one center in Poland and one center in The Netherlands will be enrolled and randomized to examination of either of the two methods.
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Notify Me50 year–80 year
All sexes
Interventional
Not applicable
Sorlandet Hospital, Arendal, Norway
Single blinded randomized controlled trial.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Water is infused and suctioned in a systematic fashion to obtain luminal view and for cleansing of the colon to facilitate colonoscope insertion. The carbon dioxide pump is turned off, only to be turned on during withdrawal from the cecum.
Other names: Water exchange
Carbon dioxide insufflation to obtain luminal view to facilitate colonoscope insertion, considered to be standard procedure.
Other names: Carbon dioxide
Time frame: 1 hour
Patients will be asked by a blinded assistant immediately after colonoscopy to score pain during the procedure.
Time frame: 30 minutes
Patients will be asked to report pain during colonoscopy to an unblinded study assistant.
Time frame: 1 hour
Cecal intubation rate is defined as successful completion of colonoscopy insertion. This will be analyzed on an intention-to-treat basis according to group allocation.
Time frame: 1 hour
The time taken to complete insertion of the colonoscope.
Time frame: 1 hour
Detection of adenomas during each colonoscopy procedure
Time frame: 1 hour
Detection of any colonic polyp, irrespective of histologic type, during each procedure.
Time frame: 1 hour
Dose of sedative and analgesic medication needed to complete the colonoscopy.
Sorlandet Hospital HF
Other Gov
Water Exchange Versus Carbon Dioxide Insufflation to Improve Colonoscopy Screening - a Randomized Controlled Trial
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