Wasting in Chronic Kidney Disease

Protein energy wasting is an independent factor associated with morbi-mortality in chronic kidney disease. Wasting is particularly common in chronic diseases of organs such as kidney disease with a major impact at the stage of dialysis. It covers 20 to 70% of patients diagnosed with chronic kidney disease according to the degree of evolution of the disease and the diagnostic method.

Mechanisms of PEW are based mainly on anorexia and metabolic abnormalities caused by kidney disease. Nutritional treatment differs depending on the stage of the kidney disease acute or chronic treated whether or not by dialysis. Nutritional monitoring should be regular, individualized and collaborative to detect a risk of PEW or treat installed PEW. Refeeding techniques should allow all the nutritional needs. Their indications depend on the clinic, biochemical assessment and nutrient intake.

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Key information

Conditions

Chronic Kidney Hospitalized Body Weight Body Weight Changes Cachexia Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hyperphagia Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Signs and Symptoms Signs and Symptoms, Digestive Thinness Urogenital Diseases Urologic Diseases Weight Loss

Age range

44 year–73 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with kidney disease
Patients hospitalized in a university hospital renal ward

Exclusion criteria

Hospitalization less than two weeks

Treatment and study plan

Nutritional care

Dietary Supplement

Diagnosis of protein energy wasting : anthropometry, calculation of the nutrient intakes, evaluation of appetite, evaluation of gastrointestinal syndromes, hand grip test and bioimpedancemetry
Treatment of protein energy wasting : estimation of nutritional requirements, prescription of oral nutritional supplement or artificial nutrition, physical rehabilitation
Multidisciplinary approach (nephrologists, dieticians, physiotherapists, nurses)
Evaluation of the nutritional treatment (plasma albumin and prealbumin, weight evolution, muscle strength and body composition)

Primary outcomes

Nutritional care evaluated with questionnaire

Time frame: Since admissions to hospital, up to 4 weeks

Secondary outcomes

body composition

Time frame: Since admissions to hospital, up to 4 weeks
physical activity

Time frame: Since admissions to hospital, up to 4 weeks

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Wasting in Chronic Kidney Disease: Refeeding Techniques and Artificial Nutrition Practices

Acronym: PEW

Important dates

Study start: 2011
Primary completion: 2012
Study completion: 2012
First posted: May 1, 2017
Registry last updated: May 1, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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