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NCT Number: NCT07181317

WAMIF: Prospective Study in Young Women Presenting Acute Myocardial Infarction: Cohort Follow up

The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients.

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Key information

Conditions

Myocardial Infarction, Acute Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year–60 year

Sex eligibility

Female

Study type

Observational

Primary location

Hôpital de la Pitié Salpétrière

Paris, 75012, France

Location status: Recruiting

Location contact

Stéphane MANZO-SILBERMANN, MD

CONTACT

About this study

The WAMIF study was conducted from 2017 to 2019, including 314 patients in 30 French research centers spread across metropolitan France. It systematically collected the clinical, morphological, and biological characteristics of myocardial infarction cases affecting women under 50 years of age and assessed their short-term (in-hospital) and medium-term (12-month) prognosis. The main results were: a particularly high incidence of modifiable risk factors affecting 86% of patients, with smoking being the primary cause in 75% of them.The clinical presentation found chest pain in more than 90% of cases. The pathophysiological forms of acute coronary syndrome identified the culprit artery in 90% of cases, a form without obstruction (MINOCA) was found in 17.8% of ST segment elevation infarctions (STEMI), spontaneous dissection in 14.6% of STEMI and 16.3% of NSTEMI.At 12 months, follow-up showed no cardiovascular deaths and two deaths related to neoplastic causes. At the end of this follow-up, 90% had no events. Compared to existing studies, these event rates are extremely low. Extending the follow-up beyond 12 months for this first study would provide fundamental data for understanding and improving the care of these patients. The secondary objective is the evaluation of the quality of life and mental health of women who have had an MI before the age of 50 years at a distance from the acute event.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

All patients who participated in the WAMIF study (research registration number with the French Ministry of Health : 2015-A01263-46 / Protocol registration with Clinical Trials NCT03073447) and wish to continue follow-up in the study.

Treatment and study plan

questionnaires

Other

Assessment of stress and anxiety and quality of life after myocardial infarct:

  • Stress score: Perceived Stress Scale-4 (PSS-4)
  • Anxiety score: Generalized Anxiety Disorder-7 (GAD-7)
  • Depression score: Patient Health Questionnaire-9 (PHQ-9)
  • Quality of life scores: European Quality of Life-5 Dimensions (EQ-5D) and 12-Item Short-Form General Health Survey (SF-12)

Major events

Other

Collection of information related to major events occurring since inclusion in the WAMIF study

Primary outcomes

  1. Death from any cause

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who died from any cause since their participation in WAMIF study

  2. Cardiovascular death

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who died from cardiovascular cause since their participation in WAMIF study

  3. Stent thrombosis

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had stent thrombosis since their participation in WAMIF study

  4. Stroke

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had stroke since their participation in WAMIF study

  5. Recurrent myocardial infarct

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had recurrent myocardial infarct since their participation in WAMIF study

  6. Emergency revascularization

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had emergency revascularization since their participation in WAMIF study

  7. Major bleeding

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had since major bleeding their participation in WAMIF study

  8. Emergency hospitalization for heart failure

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who had emergency hospitalization for heart failure since their participation in WAMIF study

  9. Emergency department visit

    Time frame: 5 to 10 years after the participation in WAMIF study

    Number of patient who went to emergency department since their participation in WAMIF study

Secondary outcomes

  1. Stress score

    Time frame: 5 to 10 years after the participation in WAMIF study

    Perceived Stress Scale 4 items. It provides a total score (range 10-50, from worst to best) to assess the state of stress perceived by the patient

  2. Anxiety score

    Time frame: 5 to 10 years after the participation in WAMIF study

    Generalized Anxiety Disorder 7 items. It provides a total score to evaluate patient anxiety (range 0 to 21: 0-4: minimal anxiety; 5-9: mild anxiety; 10-14: moderate anxiety; 15-21: severe anxiety)

  3. Depression score

    Time frame: 5 to 10 years after the participation in WAMIF study

    Patient Health Questionnaire 9 items. It provides a total score (range 0-27, 1-4 minimal depression; 5-9 mild depression; 10-14 moderate depression; 15-19 moderately severe depression; 20-27 severe depression) to diagnose and measure severity of depression.

  4. Quality of life score

    Time frame: 5 to 10 years after the participation in WAMIF study

    European Quality of Life 5 Dimensions. It provides a total score (range 0-100, from worst to the best) to evaluate the generic quality of life

  5. Quality of life score

    Time frame: 5 to 10 years after the participation in WAMIF study

    12 Item Short Form General Health Survey. It determines a respondent's profile in eight fields: physical function, physical role, physical pain, general health, vitality, social functioning, emotional role, and mental health

Study contacts

Contact information is provided by the study sponsor or research team.

Tessa BERGOT, MSc

CONTACT

[email protected]

+33144907033

Sponsors and collaborators

Lead sponsor

French Cardiology Society

Other

Registry information

Official study title

WAMIF: Prospective Study in Young Women Presenting Acute Myocardial Infarction in France: Clinical, Morphological and Biological Descriptive Analysis: Cohort Follow up

Acronym: WAMIF-suivi

Important dates

Study start
2025
Primary completion
2029
Study completion
2029
First posted
Sep 18, 2025
Registry last updated
Jan 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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