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Completed

NCT Number: NCT03224533

Walnut Consumption and Diabetes Risk

Multiple NHANES surveys were combined and weighted to evaluate relationships between walnut consumption and type 2 diabetes mellitus using various independent measures of diabetes status and risk. After risks were ascertained, interactions with gender were analyzed.

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Key information

Conditions

Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California Los Angeles

Los Angeles, California, 90095, United States

About this study

Background. Dietary interventions and cohort studies of tree nuts lowering glucose levels for diabetes suggest a possible effect with walnuts. Objective. To examine the associations between walnut consumption and diabetes risk through data from the National Health and Nutrition Examination Survey (NHANES). Methods. NHANES survey data for 1999 through 2014 was pooled for adults with 24 hour recall dietary data. Risk of diabetes was based on self-report, medication use, fasting plasma glucose levels, and hemoglobin A1c (HbA1c) levels. Individuals were characterized as reporting consumption of walnuts, mixed 'nuts', or no nuts.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • NHANES data from 1999-2014 with food recalls and dietary food intake

Exclusion criteria

  • not having data on either day of the 24-hour food intake
  • individuals who consumed peanuts, but not other nuts on the day of recall, were excluded from the analysis

Treatment and study plan

Diabetes Outcome

Diagnostic Test

based on self report definition, fasting plasma glucose, and hemoglobin A1c

Primary outcomes

  1. Diabetes Outcome- self report

    Time frame: 1999-2014

    Based on self-report as told by a doctor

  2. Diabetes Outcome- Fasting Plasma Glucose

    Time frame: 1999-2014

    Based on FPG levels

  3. Diabetes Outcome- Hemoglobin A1c

    Time frame: 1999-2014

    Based on HbA1c levels

  4. Diabetes Outcome- Combined Definition

    Time frame: 1999-2014

    Based on both FPG and HbA1c levels

Secondary outcomes

  1. Sex Interaction

    Time frame: 1999-2014

    based on the previously stated definition outcomes

Sponsors and collaborators

Lead sponsor

University of California, Los Angeles

Other

Collaborators

  • California Walnut Commission

Registry information

Official study title

Association Between Walnut Consumption and Diabetes Risk in NHANES May be Gender Sex Specific

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Jul 21, 2017
Registry last updated
Jul 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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