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Completed

NCT Number: NCT06793345

Walking Training Improves Thyroid and Cardiometabolic Markers in Postmenopausal Obesity

The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:

Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.

Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).

Participants in control group will : not perform any physical training and maintain their usual daily activities.

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Key information

Conditions

Thyroid Hormones Body Weight Cardiometabolic Risk Factors Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

50 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

High Institute of Sports and Physical Education of Kef

Boulifa, Kef Governorate, 7100, Tunisia

About this study

This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body mass index≥ 30 kg.m-2.
  • Age between 50 and 60.
  • Amenorrhea for >12 months.
  • Stable eating habits.

Exclusion criteria

  • Chronic diseases.
  • Medical contraindications to physical activity.
  • Hormone replacement therapy.

Treatment and study plan

Moderate intensity intermittent walking training

Other

The intensity of the training is 60 to 80% of 6MWTdistance.

Primary outcomes

  1. Thyroid hormones

    Time frame: At baseline and after ten weeks of MIWT.

    Serum thyroid hormone concentrations are measured from a blood sample (5 ml) obtained from a prominent superficial vein in the antecubital region.

  2. Body composition

    Time frame: At baseline and after ten weeks of MIWT.

    Body composition was assessed using an electronic scale (Tanita BC-533, Tokyo, Japan),

  3. Lipid profile

    Time frame: At baseline and after ten weeks of MIWT.

    Measured by blood samples (5ml) from a prominent superficial vein in the antecubital region.

Secondary outcomes

  1. Systolic and diastolic blood pressure

    Time frame: At baseline and after ten weeks of MIWT.

    Systolic and diastolic blood pressure measurements were conducted using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA).

  2. Heart rate

    Time frame: At baseline and after ten weeks of MIWT

    Heart rate was recorded after 10 minutes of relaxation in a seated position using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA).

  3. 6 min walking test distance

    Time frame: At baseline and after ten weeks of MIWT

    It was recorded using the 6 min walking test.

  4. Perceived exertion rating

    Time frame: At baseline and after ten weeks of MIWT.

    Perceived exertion rating (RPE) was assessed with the extensively validated RPE, a 15-point scale ranging from 6 ("no exertion at all") to 20 ("maximal exertion").

Sponsors and collaborators

Lead sponsor

Wissal Abassi

Other

Registry information

Official study title

Moderate Intensity Intermittent Walking Training (MIWT) Improves Thyroid Function and Cardiometabolic Risk Factors in Obese Postmenopausal Women

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jan 27, 2025
Registry last updated
Jan 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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