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NCT Number: NCT07064382

VR-based Multi-dimensional Intervention on Cognitive Function, With AI-agents

Virtual Reality-based multi-dimensional intervention for cognition and well-being will be provided to older adults, with AI-agents. The digital health intervention include physical activity, gamification, cognitive trainings. Cognition, like memory, spatial function, sleepiness and mental health will be studied as outcomes.

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Key information

Conditions

Dementia Alzheimer Disease Behavior Brain Diseases Central Nervous System Diseases Mental Disorders Mental Health Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Pathological Conditions, Signs and Symptoms Personal Satisfaction Psychological Well-Being Signs and Symptoms Sleepiness Tauopathies

Age range

60 year–120 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

In order to study the cognitive function and well-beings, qualitative methods (like questionnaires, interviews, focus groups) and quantitative methods (like ppg, ecg, eyetracker, eeg) will be used to collect data for analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • older adults

Exclusion criteria

  • cannot attend physical activity like pedalling rehabilitation bike
  • other health issues (assessed by health professionals)

Treatment and study plan

VR-based multi-dimensional intervention

Device

VR-based multi-dimensional intervention, including LLMs, AI-agents

Primary outcomes

  1. Spatial cognition

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    mental rotation task,higher score means stronger spatial ability

  2. Spatial cognition

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    money road map test, higher score means stronger spatial ability

  3. Spatial cognition

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    building memory test, higher score means stronger spatial ability

  4. Spatial cognition

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    corsi, , higher score means stronger spatial ability

  5. Spatial cognition

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    digit span, higher score means stronger spatial ability

Secondary outcomes

  1. mental health

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    UCLA loneliness, higher score means more loneliness

  2. mental health

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    Positive and Negative Affect Schedule , 2 subscare, one is for positive, higher score means more positive affects, one is for negative, higher score mean more negetive affects

  3. mental health

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    The World Health Organization-Five Well-Being Index (WHO-5), higher score means better mental well-being

Other outcomes

  1. Sleepiness

    Time frame: pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year

    Effects on sleepiness, measured by The Pittsburgh Sleep Quality Index (PSQI)

Sponsors and collaborators

Lead sponsor

Hong Kong University of Science and Technology

Other

Registry information

Official study title

VR-based Multi-dimensional Intervention on Cognitive Function and Well-beings

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Jul 14, 2025
Registry last updated
Jul 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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