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NCT Number: NCT06559787

Volumetric Quantification of Epicardial Fat Using Semiautomated High Resolution Atrial CT Segmentation in Patients With Atrial Fibrillation Receiving Catheter Ablation

The goal of this prospective observational study is to learn about the influence of epicardial fat on the success of catheter ablation in patients with atrial fibrillation.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Atrial Fibrillation Arrhythmias, Cardiac Cardiovascular Diseases Heart Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Deutsches Herzzentrum

München, 80634, Germany

About this study

A volumetric quantification of epicardial fat is examined by dual source cardiac computet tomography in patients with paroxysmal or persistent atrial fibrillation prior to receiving their first catheter ablation for atrial fibrillation. After ablation the recurrence of arrhythmia is examined after 3 and 6 months respectively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with planned catheter ablation due to paroxysmal or persistent atrial fibrillation
  • written informed consent
  • planned computet tomography

Exclusion criteria

  • history of left atrial catheter ablation
  • minor patients or patients not capable of giving written informed consent
  • contraindication for computet tomography with contrast agents (e.g. allergy to contrast agents or relevant renal insufficiency or hyperthyreosis)
  • patients with congenital heart defects or history of cardial surgery

Treatment and study plan

Primary outcomes

  1. Influence of epicardial adipose tissue (EAT) volume on 1 year arrhythmia recurrences after catheter ablation

    Time frame: measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months

    influence of EAT volume quantified by volumetric CT segmentation on 1 year arrhythmia recurrences after catheter ablation for paraxysmal or persistent atrial fibrillation

Secondary outcomes

  1. associations between EAT and gender, BMI, cholesterol levels, body fat

    Time frame: measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months

    associations between EAT and gender, BMI, cholesterol levels, body fat

  2. associations between EAT and left atrial wall thining

    Time frame: measurement of epicardial fat at baseline; anamnestic and ECG-control of arrhythmia after 3, 6 and 12 months

    associations between EAT and left atrial wall thining

  3. associations between EAT and low voltage areas quantified by high density electroanatomical mapping

    Time frame: measurement of epicardial fat and catheter ablation at baseline

    associations between EAT and low voltage areas quantified by high density electroanatomical mapping

Sponsors and collaborators

Lead sponsor

Deutsches Herzzentrum Muenchen

Other

Collaborators

  • The German Heart Foundation

Registry information

Acronym: AFAT

Important dates

Study start
2022
Primary completion
2024
Study completion
2025
First posted
Aug 19, 2024
Registry last updated
Aug 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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