Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

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Key information

Conditions

IDIOPATHIC PARKINSON'S DISEASE Basal Ganglia Diseases Bone Diseases Bone Diseases, Metabolic Brain Diseases Central Nervous System Diseases Metabolic Diseases Movement Disorders Musculoskeletal Diseases Nervous System Diseases Neurodegenerative Diseases Nutritional and Metabolic Diseases Osteoporosis Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

35 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHR d'ORLEANS

Orléans, 45067, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with idiopathic Parkinson's disease according to the criteria of the UKPDBB.
Parkinson's disease of moderate severity (Index HOEHN and Yahr <5)
Patient can respond to questionnaires, with or without help

Exclusion criteria

Patients with active psychiatric illness preventing the realization of examinations
Severe Parkinson's disease (Index HOEHN and Yahr ≥5 )
Heavy-morbidity including heart failure NYHA> 3 or chronic respiratory failure, terminal or severe renal impairment known dialyzed
Pregnancy

Treatment and study plan

High resolution peripheral scanner (HRpQCT).

Other

radius and tibia osteodensitometry measurement

Primary outcomes

Measurement of volumetric bone mineral density at the tibia and radius

Time frame: 0 hour

Measurement performed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional d'Orléans

Other

Registry information

Official study title

Determinants of Volumetric Bone Mineral Density at the Tibia and Radius and it's Relationship With Osteoporotic Fractures in Idiopathic Parkinson's Disease

Acronym: DOPPA

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2017
First posted: Mar 30, 2017
Registry last updated: Mar 13, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed