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Completed

NCT Number: NCT02222142

Volatile Versus Propofol Anesthesia in OPCAB

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

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Key information

Conditions

Off Pump Coronary Artery Bypass Graft Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung medical center

Seoul, 135-710, South Korea

About this study

Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • OPCAB

Exclusion criteria

  • On pump conversion

Treatment and study plan

Isoflurane

Drug

Comparison between isoflurane and propofol, Retrospective study

Other names: inhalational anesthetics

Primary outcomes

  1. CK-MB, CRP

    Time frame: Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2

    Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2

Secondary outcomes

  1. Clinical adverse outcomes

    Time frame: until 1 year after OPCAB

    clinical adverse outcomes until postoperative 1 year

Other outcomes

  1. Cardioprotection and clinical adverse outcomes in diabetic patients

    Time frame: POD, POD 1, POD 2, one month, one year

    primary and secondary outcome analysis in diabetic patients

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Comparison of Propofol and Isoflurane Anesthesia on Cardioprotection and Clinical Outcomes in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery : A Propensity-score Analysis

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Aug 21, 2014
Registry last updated
Aug 21, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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