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OpenTrials
Completed

NCT Number: NCT01379664

Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

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Key information

Conditions

Duration of Hospitalization

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cleveland Clinic

Cleveland, Ohio, 44195, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must have surgery in G operating room suite

Treatment and study plan

Isoflurane

Drug

Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Sevoflurane

Drug

Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Primary outcomes

  1. Hospital Length of Stay

    Time frame: participants will be followed for the duration of hospital stay, an expected average of 3 days

Secondary outcomes

  1. Time-weighted Average Verbal Rating Pain Score

    Time frame: up to 72 hours after surgery

    Time-weighted average VRS (Verbal Rating Scale) pain score over the first 72 h after surgery as recorded by nurses at approximately 4-h intervals. The VRS pain score is from 0 (no pain) to 10 (worst imaginable pain).

  2. Total Intraoperative Opioid Consumption

    Time frame: intraoperative

    Total amount of opioid in IV morphine equivalents used during surgeyr

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2013
First posted
Jun 23, 2011
Registry last updated
Apr 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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