Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure

Implanted PA pressure sensors enable early detection of heart failure decompensation but are costly and invasive. Fluid retention in heart failure may affect the vocal apparatus, producing measurable voice changes that could serve as a non-invasive alternative for monitoring pulmonary congestion.

Participants record daily voice samples consisting of sustained vowel sounds and a standardized reading passage via the Noah Labs mobile app. PA pressure readings are collected daily per standard care. Voice recordings and clinical data are analyzed retrospectively using classical machine learning and deep learning approaches. No additional clinical visits are required.

Inclusion criteria

• Age 18 years or older
• Successful implantation of a PA pressure sensor and monitored by a participating study center
• Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
• Ability to comfortably read aloud the study passage in English or German
• Written informed consent obtained

Exclusion criteria

• Pregnant, breastfeeding, or unwilling to practice birth control during participation
• Condition that in the opinion of the investigator would compromise patient safety or data quality
• Pathological voice changes due to surgery or injury
• Planned invasive cardiac procedures during the study period
• COPD requiring home oxygen therapy
• Chronic kidney disease requiring dialysis
• Cognitive dysfunction limiting ability to perform daily voice recording
• Inability to read English or German
• Physical inability to use the recording device