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NCT Number: NCT06877000

Vitiligo Severity, Quality of Life, Work Productivity and Activity Impairment

translate and validate the vitiligo specific quality of life (VITIQOL) questionnaire to Arabic language.

evaluate the effect of vitiligo on patient quality of life using vitiligo specific quality of life questionnaire (VitiQoL).

measure the impact of vitiligo on work productivity using work productivity and activity impairment questionnaire (WPAI) and general self efficacy scale (GSE) .

analyze how disease severity and location influence patients quality of life and work pro

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Key information

Conditions

Vitiligo Hypopigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

About this study

Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affect the skin, hair and mucous membranes, clinically presenting as depigmented macules and leukotrichia.

Vitiligo was historically regarded as a cosmetic disorder; however, it is an immune disease as it affects patient well-being . It affects approximately 0.5-1% of the global population. A Study reported a prevalence of 1.2% in the Egyptian population.

Vitiligo is asymptomatic disease, so its effect on quality of life is much more related to psychological problems, such as lack of self-confidence unpleasant body images unsuccessful social relationships, and lower quality of marital relations, than the exclusive physical issues. It has been shown that patients with vitiligo are at risk of higher social discrimination and stigma Lesions that are more severe, on the face, or covering a greater BSA are more often associated with poorer outcomes and activity impairment.

Recently a study conducted in Egypt in 2023 noted that more than half of studied sample had low level of self-esteem and quality of life. While more than half of studied sample had moderate negative body image. Also, half of studied sample had moderate level of social problems .

limited studies have been conducted in Upper Egypt which assess life quality of patients with vitiligo and but those Studies employed non-specific tools like Dermatology Life Quality Index (DLQI).

Lilly et al have developed a reliable tool with high internal consistency named as Vitiligo specific Quality of life questionnaire(VITIQOL) that consists of 16 questions comprising of demographic and clinical parameters of the patients.

Also the work productivity and activity impairment among vitiligo patients in Egypt have not been assessed before .

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults > 18 years and less than 60 years old diagnosed with vitiligo by a physician Patients willing to complete the survey questionnaires Patients who can speak Arabic

Exclusion criteria

Patients with other major skin disease affecting QOL . Patient with chronic diseases as diabetes mellitus and hypertension Not working patients

Treatment and study plan

VITIQOL questionnaire

Other

16 questions questionnaire measure effect of vitiligo on quality of life

Other names: WPAI questionnaire and GSE scale

Primary outcomes

Arabic validated version of vitiligo specific quality of life instrument VITIQOL

Time frame: Baseline

A translated version will help to measure impact of vitiligo in Arabs
Patients with severe vitiligo which will be measured by vitiligo area scoring index VASI score , will have lower quality-of-life on vitiligo specific quality of life instrument which have a score ranges from 0 to 90

Time frame: Baseline

Vitiligo specific quality of life instrument have 15 questions each one has a likert scale from 0 to 6 , score ranges from 0-90 , patients with severe vitligo expect to have low score on the questionnaire
patients with more severe vitiligo have low work productivity and more activity impairment

Time frame: Baseline
Work Productivity and Activity impairments questionnaire is a 6 question questionnaire consists of four consists of four metric :
- Absenteeism (the percentage of work time missed)
- Presentism (the percentage of impairment experienced while at work)
- Overall work productivity loss (an estimate of combination of absenteeism and presentism)
- Activity impairment (the percentage of impairment in daily activities) WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity .

Study contacts

Contact information is provided by the study sponsor or research team.

Esraa Sa Ahmed Abdelhady, Resident

CONTACT

[email protected]

01097521695

Yasmin Mo Tawfik, Assprof

CONTACT

01006033331

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Vitiligo Severity, Quality of Life, Work Productivity and Activity Impairment Among Patients in Upper Egypt

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Mar 14, 2025
Registry last updated: Mar 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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