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OpenTrials
Completed

NCT Number: NCT01082393

Vitiligo and the Koebner Phenomenon (Model of Vitiligo Induction and Therapy: a Clinical and Immunological Analysis)

We will investigate the process of vitiligo induction and the influence of different commonly used cream treatments on this process. Studies comparing different treatments for vitiligo in the induction stage of the disease are still missing. The study hypothesis = cream treatment can stop actively spreading vitiligo lesions during the early induction stage of the disease.

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Key information

Conditions

Vitiligo Hypopigmentation Pigmentation Disorders Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University Hospital Ghent

Ghent, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female,
  • Age 18-70 years,
  • Extensive vitiligo (> 50% body surface area),
  • Patients asking for depigmenting therapy,
  • Not pregnant.

Exclusion criteria

  • Children,
  • Non extensive vitiligo (< 50% boy surface area),
  • Patients not asking for depigmenting therapies,
  • Pregnant.

Treatment and study plan

topical tacrolimus treatment

Drug

4 applications (day 1,day 3, day 6 and day10)

topical pimecrolimus treatment

Drug

4 applications (day 1, day 3, day 6 and day 10)

local mometasone furoate treatment

Drug

4 applications (day 1, day 3, day 6 and day 10)

cold cream

Drug

4 applications (day 1, day 3, day 6 and day 10)

Primary outcomes

  1. percentage of skin pigmentation in the treated area

    Time frame: after 1 day, 10 days, 30 days and 60 days

    digital image analysis system for surface measurement

Sponsors and collaborators

Lead sponsor

University Hospital, Ghent

Other

Registry information

Acronym: Koebner

Important dates

Study start
2010
Primary completion
2015
Study completion
2015
First posted
Mar 8, 2010
Registry last updated
Dec 8, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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