Vitamin K2 Supplementation in Adult Episodic Migraine

Inclusion criteria

• Adults aged 18 years or above
• History of episodic migraine with or without aura since > 12 months according to the ICHD-3 criteria.
• Migraine frequency from 4-14 days per month over the 3 months prior to screening.
• Migraine frequency from 4-14 days per month during the baseline period of assessment.
• Successful completion of the migraine diary during the baseline evaluation period.

Exclusion criteria

• Migraine patients with superimposed tension type or other forms of primary headaches
• Patients who are currently on any of the migraine prophylactic treatments (Sodium valproate, Topiramate, Beta-blockers, Tricyclic antidepressants, SRNI, Flunarizine, Verapamil, Lisinopril, Candesartan)
• Patients who have been on any of the previously listed medications within 3 months of screening
• Patient who takes the following medications:

• Ergotamine or Triptans > 10 days per month
• NSAIDs or paracetamol > 15 days per month
• Opioids more than 4 days per month
• Patients on anticoagulants
• Other active chronic pain syndromes (i.e. fibromyalgia, painful peripheral neuropathy, post-herpetic neuralgia…)
• History of hypersensitivity to the vitamin K2
• History of soy protein, cheese, eggs and meat allergy
• History of thrombotic events
• Diagnosed coagulopathy or any condition related to coagulation
• Cardiovascular event in the past month
• Current or planned pregnancy
• Lactation
• Inability to tolerate oral medications
• Known intestinal malabsorption or hypomotility syndromes
• Atrial fibrillation
• Active malignancy
• Any acute illness in the past month