Vitamin D Supplementation Prevents Elderly Pneumonia

Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.

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Key information

Conditions

Bacterial Pneumonia Avitaminosis Bacterial Infections Bacterial Infections and Mycoses Deficiency Diseases Infections Lung Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases Pneumonia Pneumonia, Bacterial Respiratory Tract Diseases Respiratory Tract Infections

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Development, Aging and Cancer, Tohoku University

1-1,Seiryo-machi,Aoba-ku,Sendai, 980-8575, Japan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Subjects are more than 65 years old and were resident in the facility for at least 6 months.
Subjects have no conditions known to interfere with vitamin D metabolism.

Exclusion criteria

Subjects are excluded if they have:

renal failure
hepatic failure
hyper- or hypo-parathyroidism
HIV infection, or malignant diseases
Subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.

Treatment and study plan

Vitamin D3

Dietary Supplement

Group A and Group C are followed without drugs and Group B is followed with vitamin D3.

Primary outcomes

prevalence of pneumonia

Time frame: one year

Secondary outcomes

all cause mortality

Time frame: one year

Sponsors and collaborators

Lead sponsor

Tohoku University

Other

Registry information

Official study title

Vitamin D Supplementation Prevents Pneumonia in Institutionalized Elderly Subjects

Important dates

Study start: 2008
First posted: Apr 7, 2009
Registry last updated: Apr 8, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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