Vitamin D Repletion in Chronic Kidney Disease

Your participation in this study requires:

• 4 visits to the outpatient clinic (including 1 screening visit)
• Providing a blood sample (less than 5 tablespoons) and a urine sample at each visit
• Taking a test to measure how leaky your gut is. This test requires that you drink a small amount of liquid (about 4 ounces) and then collect your urine for 6 hours after drinking the liquid.

Inclusion criteria

Inclusion criteria

for Healthy volunteers

• Males and post-menopausal females, between the age of 50 -80.
• Vitamin D 25-OH level less than 20 ng/ml

Inclusion criteria

for Medium-level Kidney Function volunteers

• Males and post-menopausal females, between the age of 50 -80.
• Chronic kidney disease stage 3
• Vitamin D 25-OH level less than 20 ng/ml

Exclusion criteria

• Serum calcium level >10.5 mg/dl
• Serum phosphorus level > 5.5 mg/dl
• Serum PTH level < 35 pg/ml
• Active infection including HIV, Hepatitis B or C
• History of recent acute infection ( within 1 month)
• Gastrointestinal disease resulting in significant GI dysfunction or malabsorption
• Hgb< 10 g/dL
• Current use of Coumadin
• Current use of Vitamin D >400 IU/day
• Current use of systemic steroids or other immunosuppressants
• History of malignancy not in remission (>6 months)
• History of current ethanol abuse or illicit drug use
• History of significant emotional disorder within the past 5 years
• Participation in an investigational drug study within one month of screening
• Have any other condition, which in the opinion of the investigator, should prohibit the participation in the study